Industrial Bioprocesses for the Production of Substituted Aromatic Heterocycles

Glöckler, Rainer; Roduit, Jean‐Paul

doi:10.2533/chimia.1996.413

Chimia

1996

DOI: 10.2533/chimia.1996.413

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Industrial Bioprocesses for the Production of Substituted Aromatic Heterocycles

Rainer Glöckler¹,

Jean‐Paul Roduit²

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Cited by 17 publications

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Mo–Se‐Containing Nicotinate Dehydrogenase

Dobbek

Pierik

2004

Handbook of Metalloproteins

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Se Mo‐containing nicotinate dehydrogenase (NDH) of the anaerobic soil bacterium Eubacterium barkeri catalyzes the hydroxylation of nicotinate with water and NADP + to 6‐hydroxynicotinate, one proton, and NADPH. This reaction is the first step in the degradation of nicotinate to pyruvate and propionate in a unique fermentation pathway. NDH is constituted by four different subunits and contains a Mo‐bound pyranopterin cofactor linked to cytosine dinucleotide, two different [2Fe2S] centers, and flavin adenine dinucleotide to facilitate the transfer of a hydride ion on NADP + . NDH is a member of the family of molybdenum hydroxylases and shares several distinctive features with other members of this enzyme family, such as xanthine oxidoreductase, aldehyde oxidase, and the Mo‐containing carbon monoxide dehydrogenase. The reactivity of NDH critically depends on the presence of selenium in the active site, where it is bound as a labile nonselenocysteinyl selenium ligand to molybdenum. The role of the selenium ligand is likely to accelerate the formal hydride transfer from the substrate into the Mo Se bond, displaying a novel reactivity of selenium in nature.

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Mo–Se‐Containing Nicotinate Dehydrogenase

Dobbek

Pierik

2004

Handbook of Metalloproteins

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Considerations for the Application Of Process Technologies in Laboratory‐ and Pilot‐Scale Biocatalysis for Chemical Synthesis

Ramesh

Nordblad

Whittall

et al. 2016

Practical Methods for Biocatalysis and Biotransformations 3

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Mo–Se‐Containing Nicotinate Dehydrogenase

Dobbek

Pierik

2011

Encyclopedia of Inorganic and Bioinorganic Chemistry

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Industrial Bioprocesses for the Production of Substituted Aromatic Heterocycles

Cited by 17 publications

References 0 publications

Mo–Se‐Containing Nicotinate Dehydrogenase

Mo–Se‐Containing Nicotinate Dehydrogenase

Considerations for the Application Of Process Technologies in Laboratory‐ and Pilot‐Scale Biocatalysis for Chemical Synthesis

Mo–Se‐Containing Nicotinate Dehydrogenase

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