The article is about the safety for high speed milling tools between macroscopic and mesoscale, making some analysis about the relationship between damage of cutting tools and its components and mesoscale movement, the damage of cutting tools and its components is known. With the boundary conditions of material force damage, using the material design software named MAPS to do molecular dynamics simulation, the simulation is about mesoscale state in different stress, Make sure the various mesoscale movement on stress response rate, the model of intrinsic/extrinsic about the safety for high speed milling tools on a mesoscale is established. Clear the value of intrinsic/extrinsic parameters and mesoscale movement on stress response rate. The regular pattern between damage of cutting tools and its components and mesoscale movement, which could help us to design tools, choose materials of tools and determine cutting parameters.