Currently, the issues of development of the regional economy, which require an effective solution, are becoming relevant for government and management bodies and the scientific community. One of the tools that contribute to solving the problems of the regional economy is the development of industrial cooperation. In this connection, the author made an attempt to study this process, as well as to develop comprehensive tools for managing the processes of industrial cooperation in the region (for example, Vologda Oblast). The work, on the basis of a sociological survey of the heads of enterprises of Vologda Oblast, reflects the state of cooperation in the region. An assessment of the level of development of cooperation is given, problems associated with a low level of interaction between enterprises, as well as lacking methods of efficiency from cooperation in the region are identified, in connection with which the author studied the management system of production cooperation in Vologda Oblast and proposed measures to improve it. The results obtained during the study contribute to the development and systematization of the theoretical basis of the problem under consideration. The practical significance of the work is related to the possibility of using the results of the research by researchers, graduate students, undergraduates, bachelors dealing with the problems of development of industrial cooperation.