The Italian ceramic tiles district has a long tradition but is called to face new sustainability challenges related to the profitability, the environmental impact, and the capability to offer pleasant and motivating working conditions for new young employees. New Industry 4.0 approaches are emerging to evolve the current industrial organization and are expected to enhance the overall economic, environmental, and social viability. In this context, this paper aims at demonstrating the positive correlation between the new technologies and the sustainability of the sector. It outlines the main achievements of a 4-year project financed by the Italian government, involving the entire chain made up of research centers, technology providers, and tiles producers. The presented approach is concretized in several technological innovations based on the Industry 4.0 paradigm. Furthermore, a pilot line was created to test the new systems and collect data on the process. The main results are reported in terms of improved sustainability KPIs, such as extended possibility of control of production plants, waste reduction, lower consumption of raw materials and chemical additives. Finally, a sensible increase in the operators’ digitalization level is registered, making a shift from a physical and hard working environment towards more conceptual and attractive job conditions.