Industrial-Scale Production of^99mTc Generators for Clinical Use Based on Zirconium Molybdate Gel

Molybdenum-99 production pathways and the sorbents for 99Mo/99mTc generator systems using (n, γ) 99Mo: a review

“…Several studies investigated the effect of isotopic composition of the target and irradiation parameters for the radionuclidic purity of cyclotron-produced 99m Tc [34][35][36][37]. Selivanova et al [35] reported cyclotron-produced 99m Tc-pertechnetate by the irradiation of enriched 100 Mo (99.815%; 0.17% 98 Mo; 0.003% each 92 Mo- 97 Mo) at 24 meV for 2 h. They demonstrated that the cyclotron-produced 99m Tcpertechnetate obtained at 17 meV was safe in humans. Uzunov et al [38] investigated cyclotron-produced 99m Tc using 100 Mo(p,2n) 99m Tc reaction at a proton beam energy in the range 15.7-19.4 meV.…”

“…Several researchers proposed a zirconium molybdate based gel generator which is applicable to 99 Mo obtained easily by the (n, γ) reaction of natural molybdenum [90][91][92]. El-Amir et al [93] prepared cerium (IV) tellurium molybdate based gel bed for chromatographic 99 Mo/ 99m Tc generator.…”

“…13. Marageh et al [92] reported that the produced sodium pertechnetate solution from the zirconium molybdate gel-type 99 Mo/ 99m Tc generators fulfills all requirements of U.S. pharmacopoeia as all of these generators provide high-yield and pure elution as well as sterile and pyrogen-free pertechnetate solutions. In addition, it shows favorable-quality features to prepare various 99m Tc complexes.…”