“…Interruptions of these rhythms fr om such artificial time reorganizations as shift work have been reported to result in damage to worker performance and output (117)(118)(119)(120) and to be associated with increased accident rates (121), feelings of less well-being (122,123), increased rates of gastrointesti nal disorders (124)(125)(126)(127), neuropsychiatric disorders including depression, anxiety, and confusion (121,125,127,128), drug abuse (121,129), and sleep disturbances (124,126,130,131).…”