In order to meet the increasingly complex expectations of customers, many companies must increase efficiency and agility. In this sense, Industry 4.0 technologies offer significant opportunities for improving both operational and decision-making processes. These developments make it possible to consider an increase in the level of operational systems and teams’ autonomy. However, the potential for strengthening the decision-making process by means of these new technologies remains unclear in the current literature. To fill this gap, a Delphi study using the Régnier Abacus technique was conducted with a representative panel of 24 experts. The novelty of this study was to identify and characterize the potential for enhancing the overall decision-making process with the main Industry 4.0 groups of technologies. Our results show that cloud computing appears as a backbone to enhance the entire decision-making process. However, certain technologies, such as IoT and simulation, have a strong potential for only specific steps within the decision-making process. This research also provides a first vision of the manager’s perspectives, expectations, and risks associated with implementing new modes of decision-making and cyber-autonomy supported by Industry 4.0 technologies.