This comprehensive review explores the application and impact of business analytics in healthcare management, focusing on the distinctive perspectives of the United States and Africa. In an era where data-driven decision-making is paramount, healthcare organizations globally are increasingly turning to business analytics to enhance efficiency, improve patient outcomes, and optimize resource allocation. The review begins by examining the state of business analytics in healthcare management within the United States, a pioneer in adopting advanced analytics solutions. The analysis encompasses the utilization of predictive modeling, data mining, and artificial intelligence to streamline operations, enhance clinical decision-making, and improve patient care. Case studies and success stories from leading healthcare institutions in the USA illustrate the transformative power of business analytics in areas such as patient risk stratification, resource optimization, and population health management. Contrastingly, the review delves into the unique challenges and opportunities that characterize the adoption of business analytics in healthcare across the African continent. Despite facing resource constraints and varying levels of technological infrastructure, African nations are increasingly recognizing the potential of analytics to address pressing healthcare challenges. The discussion encompasses initiatives and collaborations aimed at leveraging data analytics to improve healthcare delivery, disease surveillance, and resource management in the African context. The comparative analysis between the USA and Africa highlights the diversity of approaches and contexts in implementing business analytics in healthcare management. Factors such as data accessibility, infrastructure development, and cultural considerations emerge as critical determinants shaping the successful integration of analytics tools in healthcare decision-making. The review underscores the pivotal role of business analytics in reshaping healthcare management practices, while acknowledging the need for tailored strategies that align with the specific challenges and opportunities inherent in the USA and African healthcare landscapes. This study provides valuable insights for policymakers, healthcare administrators, and researchers seeking to navigate the evolving landscape of healthcare analytics on both a global and regional scale.