The term, Dentistry 4.0, coincides with Industry 4.0, in which the traditional methods of manufacturing and information are made more precise to enhance process efficiency by using automation and advanced computer technologies. The main of this paper is to discuss the major potential of Dentistry 4.0 technologies in the field of dentistry during Coronavirus (COVID-19) Pandemic. Thereon, Dentistry 4.0 is advancing on its way with the use of advanced technologies in dentistry. Dental healthcare makes an essential part of the overall health of the masses. New technological advancements are essential to make the dentist work quicker, patient comfortable, and process reliable. So, we introduced the concept of Dentistry 4.0 to improve efficiency and impart innovation in dentistry during this pandemic. This paper briefs about the Dentistry 4.0 technologies helpful for the COVID-19 pandemic. Further discusses various issues and challenges in implementing Dentistry 4.0 for dentistry during the COVID-19 pandemic. Finally, the paper identifies and discussed fifteen significant applications of Dentistry 4.0 technologies for dentistry during the COVID-19 pandemic. With the onset of the pandemic, globally, the healthcare sector is taking initiatives to strengthen affordable and high-speed data connectivity. This up-gradation and investment will also help dentists to access patients' data from smaller towns or villages using Dentistry 4.0 technologies. Thus, globally there is the onset of the fourth dentistry revolution, and we understand that this will change the trend of dentistry during and post-COVID-19 Pandemic. Dentistry 4.0 technologies are helpful during the COVID-19 pandemic to create teledentistry, virtual clinical practice and connect all dental devices to improve health conditions. This approach is to help progress towards the integrated capabilities, patient-centric remedies with predicted results in an easier way than the traditional way of the health care industry.