The recent theory developments and latest experimental results on heavy-flavour production in Deep Inelastic Scattering and at hadron colliders are summarized. Models of heavy quarkonia production, non-perturbative corrections to fragmentation, theory of heavy-hadron production in heavy-ion collisions, and interpretation of new exotic hadrons are discussed. Progress in event generators development is reported. Most recent experimental results from HERA and e + e − colliders as well as from proton-(anti)proton and heavy ion experiments are presented and the role of charm and beauty quarks in the analyses of the proton structure is stressed.