In order to investigate the seismic safety capacity of the piping system with local wall thinning, shake table tests on 3-D piping system models were conducted using E-Defense. Two piping system models which were the same in appearance and different in degradation condition were arranged on the shake table of E-Defense. One of the models was put into degradation condition of about 50% wall thinning at four elbows and one tee. Modified seismic motions were applied to these models at the same time. As a result, the piping system model with wall thinning did not fail for the primary stress limit level of sound piping system model, though a ratchet deformation was observed on the thinned wall tee. The model with wall thinning finally failed at the thinned wall tee by over five times larger excitation than the limit level. From the experiment, it was found that the life of the piping system with wall thinning would be reduced compared with that of the piping system without wall thinning, but it was also found that the degraded piping system still had a certain seismic margin until the piping system failed by the seismic load.