Inequalities in Meningioma Survival: Results from the National Cancer Database

Yang, Andrew; Mensah-Brown, Kobina; Rinehart, Cole; Fathy, Ramie; Hitti, Frederick L; Brant, Jason A.; Lee, John Y.K.

doi:10.7759/cureus.7304

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…19 World while, WHO grade III meningiomas show extremely aggressive behavior and high rates of recurrence. 20 In our study, in accordance to the histological type, the microcystic meningiomas (WHO I) had a surveillance rate of 60 months (lowest) in contrast with transitional (WHO I) with 122 months (highest). For the non-graphed variants, not enough censored data were obtained, so no data was obtained from them.…”

Section: Discussionsupporting

confidence: 57%

Progression Free -survival According to Simpson Grade Resection and Histological Types of Meningiomas in the Mexican Population Progression Free-survival of Meningiomas in the Mexican Population

Hernández¹,

Moreno²,

Domínguez³

et al. 2021

Preprint

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Introduction: Meningiomas are the most common primary central nervous system (CNS) tumors, with an incidence of 8.14 per 100,000 habitants. They represent 30% of all adult primary brain tumor diagnoses in the United States in contrast to Latin America with 50%. In Mexico, there are no epidemiological trends of meningiomas or other CNS tumors. Simpson resection grade and WHO grade are the prognostic factors with the greatest effect. In this paper, we describe the correlation between the survival free of disease and the gross total resection with its histological type according to Simpson’s grading scale. Materials and methods: A descriptive, analytical, retrospective, case-control study was conducted in two public third -level hospitals and three second- level hospitals in two cities of Mexico, (Mexico City and Guadalajara, Jalisco in a period of 10 years (2010-2020). An analysis of measures of central tendency was performed for age, sex, location, histological type, and postsurgical Simpson grade.Results: 26 patients of 179 had recurrence. Among the total recurrences, 15.4% were Simpson 1, 69.2%Simpson 2, and 15.4%Simpson 3. The survival for Simpson 1 was 142.0 months, Simpson 2 90.32 months, and Simpson 3 69.13 months. According to the histological type, the meningiomas with the lowest survival were the microcystic ones with 60 months, followed by the atypical ones with 90.4 months, and the psammomatous ones with 99.8 months. Conclusion: Surgical resection and the histological type are factors that affect progression free -survival. The Mexican population presents characteristics similar to those described in world literature.Importance of the study: This is the first study of its kind in the Mexican population and lays the foundations for future studies in the Latin American population.

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Section: Discussionsupporting

confidence: 57%

Progression Free -survival According to Simpson Grade Resection and Histological Types of Meningiomas in the Mexican Population Progression Free-survival of Meningiomas in the Mexican Population

Hernández¹,

Moreno²,

Domínguez³

et al. 2021

Preprint

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“…The heterogeneity of this population can likely account for some of the con icting results thus far in the literature demonstrating either no difference or improved OS for Hispanic patients with meningiomas. 7,[14][15][16] We subclassi ed Hispanic ethnicity into Hispanic White and Hispanic Black to account for this admixture and its potential in uence on outcome. Hispanic White populations have signi cantly improved OS compared to White populations.…”

Section: Discussionmentioning

confidence: 99%

“…2,5,6 However, Hispanic patients have similar or improved OS compared to White patients. 7 Given that the Hispanic population has been noted to have similar SES compared to Blacks, it suggests other factors, perhaps related to differences in tumor biology amongst races and ethnicities, may contribute to the disparities observed in OS after meningioma resection.…”

Section: Introductionmentioning

confidence: 99%

Meningioma Characteristics Influencing Overall Survival by Race and Ethnicity

Dincer,

Tabor,

Pappajohn

et al. 2024

Preprint

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Background There are known racial and ethnic disparities affecting overall survival (OS) in meningiomas. This has largely been presumed to be due to differences in socioeconomic status (SES). However, there are conflicting studies that demonstrate better survival for Hispanic compared to Black populations, two groups with similar SES. Thus, we hypothesize additional underlying factors, including tumor biology, may differ amongst race and influence OS of patients with meningioma. Methods We queried the NCDB for patients with pathology-confirmed meningiomas from 2012-2020. Race and ethnicity were self-reported and grouped into White, Hispanic White, Black, Hispanic Black, and Asian categories. Logistic regression analyses were performed to determine tumor and patient characteristics associated with race and Cox hazards model was performed on these characteristics to determine influence on OS. Results We included 85,244 patients in this study. Black patients have worse OS compared to White patients. Black patients were also more likely to harbor higher grade tumors and undergo subtotal resection compared to White patients. Hispanic White patients had improved overall survival (P<0.0001) with less higher-grade tumors (P=0.0051) compared to White patients. There was no difference in overall survival for Hispanic Black patients (P=0.49) despite being more likely to have higher grade tumors (P=0.0164). Conclusions Differences in meningioma biology may contribute to the differences in OS seen in racial groups beyond SES. Black patients are a particularly vulnerable group as they tend to harbor higher-grade tumors and undergo less aggressive surgical resections. Further studies are necessary to determine possible differences in underlying biology.

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“…The presence of inequalities in both disease presentation and treatment outcomes significantly impacts the well-being and survival of patients. In this context, studies have examined healthcare, demographic, and socioeconomic factors that contribute to diverse patient outcomes and HRQoL [51].…”

Section: Inequality In Hrqol Of Patients With Meningiomamentioning

confidence: 99%

Quality of Life in Patients with Meningioma

Merati,

Montazeri,

Mohebi

et al. 2024

Meningioma - The Essentials From Bench to Bedside

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Meningiomas are common benign brain tumors that may significantly impact patients’ Health-Related Quality of Life (HRQOL) and functional disability. The assessment of HRQOL in meningioma patients is heterogeneous, necessitating standardized approaches. Patient-Reported Outcome Measures (PROMs) are increasingly used to capture patients’ perspectives, with various questionnaires developed for this purpose. Medical and non-medical risk factors for long-term HRQOL impairment encompass tumor characteristics, treatment factors, and sociodemographic features. Symptomatic meningioma patients experience lower HRQOL scores, with symptoms influenced by tumor features such as location, edema, and size. Prominent subsequent manifestations, including epilepsy, neurocognitive dysfunction, and psychiatric symptoms, significantly influence HRQOL. Surgical resection is the primary therapeutic option, and adjuvant radiotherapy may be considered for recurrent or high-risk cases. Although patients generally experience improved HRQOL post-surgery, some may face long-term declines, necessitating comprehensive long-term well-being evaluation. Patients often undergo positive changes in mental outlook (posttraumatic growth), triggering a “response shift” that may alter patients’ values and internal standards, ultimately improving their perception of HRQOL. Long-term outcomes highlight meningioma’s chronic impact on patients’ lives and socioeconomic burden. Overall, understanding and addressing these factors optimizes patients’ well-being and functional outcomes. A holistic approach considering medical and psychosocial aspects is crucial for enhancing HRQOL in meningioma patients.

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Inequalities in Meningioma Survival: Results from the National Cancer Database

Cited by 10 publications

References 10 publications

Progression Free -survival According to Simpson Grade Resection and Histological Types of Meningiomas in the Mexican Population Progression Free-survival of Meningiomas in the Mexican Population

Progression Free -survival According to Simpson Grade Resection and Histological Types of Meningiomas in the Mexican Population Progression Free-survival of Meningiomas in the Mexican Population

Meningioma Characteristics Influencing Overall Survival by Race and Ethnicity

Quality of Life in Patients with Meningioma

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