Inequality in Zika virus and congenital Zika syndrome

Diderichsen, Finn; Augusto, Lia Giraldo da Silva

doi:10.1016/b978-0-12-820268-5.00004-3

Zika Virus Biology, Transmission, and Pathology 2021

DOI: 10.1016/b978-0-12-820268-5.00004-3

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Inequality in Zika virus and congenital Zika syndrome

Finn Diderichsen¹,

Lia Giraldo da Silva Augusto²

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2024

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Cited by 1 publication

References 60 publications

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Landscape of Host Genetic Factors Correlating with SARS-CoV

Hussain,

Ali,

Khan

et al. 2024

From SARS-CoV to MARS-CoV

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The host’s wide range of genetic variation plays an essential role in determining the susceptibility, severity, and overall pathological conditions of coronavirus disease-19 (COVID-19) following infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). COVID-19, caused by SARS-CoV, is a zoonotic disease that has affected humans after crossing boundaries. Emerging viral infections typically result from the host when a virus transfers from the very first host into a new species. There is substantial diversity in illness progress among patients infected with SARS-CoV-2. Many do not show any manifestations, while others progress to acquire COVID-19; nonetheless, the intensity of COVID-19 symptoms substantially ranges among people. Host factors such as age, gender, geographical region, diseases, co-morbidities, and various host genetic factors predispose susceptibility to SARS-CoV-2 infection. Individuals who possess certain variations of genes directly implicated in viral infection (e.g., ACE2, TMPRSS2) or who have differential expression of those genes may be more susceptible to SARS-CoV-2. These alterations might account for the wide variety of symptoms and severity of COVID-1- -related SICKNESS in various people. Because the behavior of the infectious agent varies so much across strains, the impacts of individual variation are best evident when the same strain of an organism infects previously unexposed people simultaneously. An increase in genetic diversity in host sensitivity to pathogenic agents has been related to the development of major-effect resistance polymorphisms among populations.

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Landscape of Host Genetic Factors Correlating with SARS-CoV

Hussain,

Ali,

Khan

et al. 2024

From SARS-CoV to MARS-CoV

View full text Add to dashboard Cite

show abstract

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Inequality in Zika virus and congenital Zika syndrome

Cited by 1 publication

References 60 publications

Landscape of Host Genetic Factors Correlating with SARS-CoV

Landscape of Host Genetic Factors Correlating with SARS-CoV

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