In this paper, we propose two inertial algorithms with a new self-adaptive step size for approximating a solution of the split common null-point problem in the framework of Banach spaces. The step sizes are adaptively updated over each iteration by a simple process without the prior knowledge of the operator norm of the bounded linear operator. Under suitable conditions, we prove the weak-convergence results for the proposed algorithms in p-uniformly convex and uniformly smooth Banach spaces. Finally, we give several numerical results in both finite- and infinite-dimensional spaces to illustrate the efficiency and advantage of the proposed methods over some existing methods. Also, data classifications of heart diseases and diabetes mellitus are presented as the applications of our methods.