Infant Colic—What works

Harb, Tracy; Matsuyama, Misa; David, Michael; Hill, Rebecca J.

doi:10.1097/mpg.0000000000001075

Cited by 79 publications

(38 citation statements)

References 63 publications

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“…Thus, our analysis more precisely defines the role of probiotics for treating infantile colic. A more recent systematic review by Harb et al [17] focused on interventions in breast-fed infants only and concluded that probiotics, in particular L. reuteri , appear effective for reducing colic, although there are limitations to these findings.…”

Section: Discussionmentioning

confidence: 99%

Probiotics for management of infantile colic: a systematic review of randomized controlled trials

Dryl

Szajewska

2018

aoms

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IntroductionInfantile colic is a common pediatric problem. The cause of infantile colic remains unclear. Treatment options are limited. Evidence suggests that probiotics might offer some benefit. The aim of the study was to systematically assess the effectiveness of probiotics supplementation in the management of infantile colic.Material and methodsMEDLINE and the Cochrane Library were searched up to April 2016 for randomized controlled trials (RCTs) evaluating the efficacy of probiotics (any well-defined strain) compared with placebo for the management of infantile colic. The outcome measures of interest were treatment success and the duration of crying at the end of the intervention.ResultsSeven RCTs (471 participants) were included. Compared with placebo the administration of Lactobacillus reuteri DSM 17938 at a daily dose of 108 CFU was associated with the treatment success (relative risk = 1.67, 95% CI: 1.10–2.81, number needed to treat 5, 95% CI: 4–8) and reduced crying times at the end of the intervention (mean difference: –49 min, 95% CI: –66 to –33); however, the effect was mainly seen in exclusively breastfed infants. Other probiotics (single or in combinations) were studied in single trials only.ConclusionsSome probiotics, primarily L. reuteri DSM 17938, may be considered for the management of infantile colic. Data on other probiotics are limited.

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Section: Discussionmentioning

confidence: 99%

Probiotics for management of infantile colic: a systematic review of randomized controlled trials

Dryl

Szajewska

2018

aoms

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“…Different studies provided sufficient evidence to conclude in meta-analyses that Lactobacillus reuteri DSM 17938 at a dose of 10 8 colony-forming units per day in breastfed infants decreased IC and was well tolerated and safe [2324], resulting in a reduction of parental discomfort and the number of consultations [13]. One study in mainly formula fed infants with the same L. reuteri strain yielded a negative result [25].…”

Section: Discussionmentioning

confidence: 99%

Innovative Dietary Intervention Answers to Baby Colic

Xinias

Analitis

Mavroudi

et al. 2017

Pediatr Gastroenterol Hepatol Nutr

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PurposeThe purpose of this paper is to evaluate the efficacy of a lactose- reduced synbiotic partial whey hydrolysate in formula fed infants presenting with colic and the impact of this dietary intervention in mean crying time and quality of life.MethodsForty infants with infantile colic were treated during one month with parental reassurance and the intervention formula (partial whey hydrolysate, reduced lactose, Bifidobacterium lactis BB12 and galacto-oligosaccharides) and were compared to a control group of 20 infants with infantile colic treated with parental reassurance and a standard infant formula. Parents completed a quality of life (QoL) questionnaire assessing the burden of infantile colic. Wilcoxon test, t-test and Mann-Whitney test were used to compare QoL scores before and after intervention as well as between the intervention and control group.ResultsAt inclusion, duration of crying did not differ between both groups. Crying duration decreased with 2.7 hours (from 3.2 to 0.5 hours) in the intervention group while duration of crying decreased only with 1.2 hours in the control group (p<0.001). Stool composition became looser in the intervention group, but defecation frequency did not change. The median scores of the QoL questionnaire improved significantly in the intervention group for all parameters. In the control group, parameters improved significantly also but not for the parent-child and social interaction. The score changes were significantly greater in the intervention than in the control group.ConclusionThe intervention formula (partial whey hydrolysate, synbiotic, reduced lactose) significantly reduced the duration of crying and improved QoL of the parents and infants.

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“…Concerns have been raised with regard to the impact of proton pump inhibitors on the gut microbiome and the association between using proton pump inhibitors and small bowel bacterial overgrowth in children 33, 34. There is sparse evidence for the efficacy of other medication, such as pain relieving agents, prokinetic drugs or over‐the‐counter remedies such as simethicone for treating infantile colic 28, 35, 36, 37, 38. However, parents of infants with colic are very likely to decide what medication they give their children without advice from their doctor 39, 40.…”

Section: Pharmacological Management Of Fgids In Early Lifementioning

confidence: 99%

Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants

et al. 2018

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AimRegurgitation, infantile colic and functional constipation are common functional gastrointestinal disorders (FGIDs) during infancy. Our aim was to carry out a concise review of the literature, evaluate the impact of these common FGIDs on infants and their families, and provide an overview of national and international guidelines and peer‐reviewed expert recommendations on their management.MethodsNational and international guidelines and peer‐reviewed expert recommendations on the management of regurgitation, infantile colic and functional constipation were examined and summarised.ResultsRegurgitation, infantile colic and functional constipation cause frequent parental concerns, lead to heavy personal and economic costs for families and impose a financial burden on public healthcare systems. Guidelines emphasise that the first‐line management of these common FGIDs should focus on parental education, reassurance and nutritional advice. Nutritional advice should stress the benefits of continuing breastfeeding, while special infant formulas may be considered for non‐breastfed infants with common FGIDs. Drug treatment is seldom required, with the exception of functional constipation.ConclusionBy providing complete and updated parental education, reassurance and nutritional advice, healthcare professionals can optimise the management of FGIDs and related symptoms and reduce the inappropriate use of medication or dietary interventions.

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Infant Colic—What works

Cited by 79 publications

References 63 publications

Probiotics for management of infantile colic: a systematic review of randomized controlled trials

Probiotics for management of infantile colic: a systematic review of randomized controlled trials

Innovative Dietary Intervention Answers to Baby Colic

Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants

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