Infant death among children whose mothers took folic acid during early pregnancy – Sino–US NTD Project

Berry, R. J.; Li, Z; Gindler, Jacqueline; Jm, Liu; Zheng, Jc; Correa, Adolfo; Wang, H; Wong, Ly; Wang, Y

doi:10.1111/j.1365-3016.2001.381-10.x

Cited by 1 publication

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“…Some of the studies we reviewed also suggest that increased intakes of folic acid and other nutrients are associated with reduced risk of other congenital birth defects 40,41,63,65 . Unpublished findings based on follow‐up of offspring in the SINO‐US NTD prevention project have shown that daily consumption of 400 µg of folic acid during the periconceptional period was associated with reduced infant mortality among infants without major birth defects (RR = 0.78 [95% CI 0.72, 0.85]) and improved linear growth 92,93 . There were no differences in behaviour and cognitive development during early childhood in the same study population 94,95 in contrast to a recent study in which maternal consumption of supplements containing folic acid during the periconceptional period (4 weeks before pregnancy to <8 weeks gestation) was associated with a significant reduction (20%) in the risk of moderate language delay among the offspring (singleton non‐intrauterine growth restriction) at 3 years of age in a Norwegian birth cohort 96 .…”

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confidence: 96%

Effect of Women's Nutrition before and during Early Pregnancy on Maternal and Infant Outcomes: A Systematic Review

Ramakrishnan

Grant

Goldenberg³

et al. 2012

Paediatric Perinatal Epid

425

362

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Current understanding of biologic processes indicates that women's nutritional status before and during early pregnancy may play an important role in determining early developmental processes and ensuring successful pregnancy outcomes. We conducted a systematic review of the evidence for the impact of maternal nutrition before and during early pregnancy (<12 weeks gestation) on maternal, neonatal and child health outcomes and included 45 articles (nine intervention trials and 32 observational studies) that were identified through PubMed and EMBASE database searches and examining review articles. Intervention trials and observational studies show that periconceptional (<12 weeks gestation) folic acid supplementation significantly reduced the risk of neural tube defects. Observational studies suggest that preconceptional and periconceptional intake of vitamin and mineral supplements is associated with a reduced risk of delivering offspring who are low birthweight and/or small-forgestational age (SGA) and preterm deliveries (PTD). Some studies report that indicators of maternal prepregnancy size, low stature, underweight and overweight are associated with increased risks of PTD and SGA. The available data indicate the importance of women's nutrition prior to and during the first trimester of pregnancy, but there is a need for well-designed prospective studies and controlled trials in developing country settings that examine relationships with low birthweight, SGA, PTD, stillbirth and maternal and neonatal mortality. The knowledge gaps that need to be addressed include the evaluation of periconceptional interventions such as food supplements, multivitamin-mineral supplements and/or specific micronutrients (iron, zinc, iodine, vitamin B-6 and B-12) as well as the relationship between measures of prepregnancy body size and composition and maternal, neonatal and child health outcomes.

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Section: Commentsmentioning

confidence: 96%