Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates

Neudecker, Viola; Perez‐Zoghbi, Jose F.; Coleman, Kristine; Neuringer, Martha; Robertson, Nicola; Bemis, Alexandra; Glickman, Bess; Schenning, Katie J.; Fair, Damien A.; Martin, Lauren Drew; Dissen, Gregory A.; Brambrink, Ansgar M.

doi:10.1016/j.bja.2020.10.015

Cited by 37 publications

(42 citation statements)

References 67 publications

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“…Neuronal and oligodendroglial cell death in macaques is evident in subcortical regions following prenatal anesthetic exposure and in various laminae of sensory regions if exposure occurs after birth 54 but are less marked than in rodents. 55,56 In humans, the literature regarding the effect of neonatal anesthetic exposure on subsequent development is much less coherent. Although there is general agreement that repeated neonatal anesthesia is undesirable, 42 its impact on later learning and behavior is confounded by other variables (eg, the underlying condition that required anesthesia).…”

Section: Postnatal Development Of Neurotransmitter Systemsmentioning

confidence: 99%

Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development

Zeiss

2021

Toxicol Pathol

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Within the substantially different time scales characterizing human and rodent brain development, key developmental processes are remarkably preserved. Shared processes include neurogenesis, myelination, synaptogenesis, and neuronal and synaptic pruning. In general, altricial rodents experience greater central nervous system (CNS) immaturity at birth and accelerated postnatal development compared to humans, in which protracted development of certain processes such as neocortical myelination and synaptic maturation extend into adulthood. Within this generalization, differences in developmental rates of various structures must be understood to accurately model human neurodevelopmental toxicity in rodents. Examples include greater postnatal neurogenesis in rodents, particularly within the dentate gyrus of rats, ongoing generation of neurons in the rodent olfactory bulb, differing time lines of neurotransmitter maturation, and differing time lines of cerebellar development. Comparisons are made to the precocial guinea pig and the long-lived naked mole rat, which, like primates, experiences more advanced CNS development at birth, with more protracted postnatal development. Methods to study various developmental processes are summarized using examples of comparative postnatal injury in humans and rodents.

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Section: Postnatal Development Of Neurotransmitter Systemsmentioning

confidence: 99%

Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development

Zeiss

2021

Toxicol Pathol

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“…Twelve (12/23) studies reported that all animals survived the anesthetic procedure 24,26–29,33,34,37–40,42 . Other 11/23 studies did not address animal survival following exposure 16,22,23,25,30–32,35,36,41,43 .…”

Section: Resultsmentioning

confidence: 99%

Anesthesia and neurotoxicity study design, execution, and reporting in the nonhuman primate: A systematic review

Gao

Wahl

Floyd

2022

Pediatric Anesthesia

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The potential for anesthetics to cause neurodevelopmental delay in neonates has been supported by hundreds of animal studies in rodents and more recently supported by fewer studies in nonhuman primates (NHP). Largely in response to these studies the Federal Drug Administration (FDA), in 2016, issued a "Drug Safety Communication" 1 warning that general anesthetics and sedation drugs used in children less than 3 years of age or in pregnant women in their third trimester who were undergoing anesthesia for more than 3 h or repeated use of anesthetics "may affect the development of children's brains." 2

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“…Our study, along with above two researches, indicated an inspiring possibility that a self‐recovery mechanism exists. However, other studies in infant rhesus monkeys suggest that inhalation anaesthetics affect social behaviours, but do not impair specific cognitive domains, 45,46 which imply further investigations are needed to elucidate the potential neurotoxicity of inhalation anaesthetics on developing brains.…”

Section: Discussionmentioning

confidence: 99%

Maternal sevoflurane exposure induces temporary defects in interkinetic nuclear migration of radial glial progenitors in the fetal cerebral cortex through the Notch signalling pathway

et al. 2021

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Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates

Cited by 37 publications

References 67 publications

Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development

Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development

Anesthesia and neurotoxicity study design, execution, and reporting in the nonhuman primate: A systematic review

Maternal sevoflurane exposure induces temporary defects in interkinetic nuclear migration of radial glial progenitors in the fetal cerebral cortex through the Notch signalling pathway

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