Infant outcome of 957 singletons born after frozen embryo replacement: The Danish National Cohort Study 1995–2006

Pinborg, Anja; Loft, Anne; Henningsen, Anna-Karina Aaris; Rasmussen, Steen; Andersen, Anders Nyboe

doi:10.1016/j.fertnstert.2009.05.091

Cited by 252 publications

(206 citation statements)

References 38 publications

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“…This finding is in line with systematic reviews and cohort studies which indicated similar or even better neonatal outcomes for singletons born after cryopreservation of the embryo compared to singletons born after IVF/ICSI with fresh embryo transfer [1][2][3][4][5][6].…”

Section: Introductionsupporting

confidence: 88%

Is IVF/ICSI with Fresh Embryo Transfer Associated with Higher Mean Singleton Birth Weight Compared to Spontaneous Conception?

Neumann¹,

Cirkel²,

Alex³

et al. 2017

J Preg Child Health

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Section: Introductionsupporting

confidence: 88%

Is IVF/ICSI with Fresh Embryo Transfer Associated with Higher Mean Singleton Birth Weight Compared to Spontaneous Conception?

Neumann¹,

Cirkel²,

Alex³

et al. 2017

J Preg Child Health

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“…In fresh donor cycles, recipients have hormone levels more comparable to those in a natural conception cycle, which may in part explain the improved rates of implantation, clinical pregnancy, and live births [38], as well as lower rates of LBW, SGA [8], and preterm birth [5]. Results of clinical studies and meta-analyses of IVF pregnancies indicate the risks for SGA, preterm birth, LBW, antepartum hemorrhage, and perinatal mortality are significantly reduced with frozen compared to those with fresh embryo transfers [2,[39][40][41][42]. The risk of prenatal bleeding, placental complications, and postpartum hemorrhage has been shown to be higher in both subfertile and IVF pregnancies compared to those conceived spontaneously [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles

Luke

Brown

Wantman³

et al. 2016

J Assist Reprod Genet

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Background Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage. LGAwas 9.2-9.8 and 14.2-15.4% in 1st and 2nd births in fresh cycles, and 13.1-15.8 and 20.8-21.0% in 1st and 2nd births in frozen cycles. The risk of LGAwas increased in frozen cycles (1st births, adjusted odds ratios (AOR) 1.74, 95% CI 1.45, 2.08; and in 2nd births when the 1st birth was not LGA, AOR 1.70, 95% CI 1.46, 1.98 for fresh/frozen and 1.40, 1.11, 1.78 for frozen/frozen). Conclusions Our results with siblings indicate that frozen embryo state is associated with an increased risk for LGA. The implications of these findings for childhood health and risk of obesity are unclear, and warrant further investigation.

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“…The rationale to use so-called segmented-ART treatment has been the avoidance of iatrogenic complications related to controlled ovarian stimulation (COS), such as, ovarian hyperstimulation syndrome (OHSS) and premature progesterone rise [3,5]. In the latter case, deferring fresh transfer, freezing all embryos, and transferring frozen-thawed embryos in a subsequent physiologically normal cycle has been shown to potentially result in improved embryo implantation and placentation and consequently improved perinatal and neonatal outcomes [1][2][3][6][7][8][9][10][11][12][13]. However, segmented treatment also has complications, i.e., the management of an increased number of confounding variables and an increase in the treatment duration.…”

Section: Introductionmentioning

confidence: 99%

Agonist depot versus OCP programming of frozen embryo transfer: a retrospective analysis of freeze-all cycles

Özgür

Berkkanoğlu

Bulut

et al. 2015

J Assist Reprod Genet

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Purpose In segmented ART treatment or so-called 'freeze-all' strategy fresh embryo transfer is deferred, embryos cryopreserved, and the embryo transferred in a subsequent frozen embryo transfer (FET) cycle. The purpose of this cohort study was to compare a GnRHa depot with an oral contraceptive pill (OCP) programming protocol for the scheduling of an artificial cycle FET (AC-FET) after oocyte pick-up (OPU). Methods This retrospective cohort study was conducted on prospectively performed segmented ART cycles performed between September 2014 and April 2015. The pregnancy, treatment duration, and cycle cancellation outcomes of 170 OCP programmed AC-FET cycles were compared with 241 GnRHa depot programmed AC-FET cycles. Results No significant difference was observed in the per transfer pregnancy and clinical pregnancy rates between the OCP and GnRHa groups, 72.0 versus 77.2 %, and 57.8 versus 64.3 %, respectively. Furthermore, the early pregnancy loss rate was non-significantly different between the OCP and GnRH protocol groups, 19.8 versus 16.7 %, respectively. However, nine (5.29 %) cycles were cancelled due to high progesterone in the OCP protocol group, while no cycles were cancelled in the GnRHa protocol group and the time taken between OPU and FET was 19 days longer (54.7 vs 35.6 days) in the OCP protocol compared to the GnRHa protocol. Conclusions The results of this AC-FET programming study suggests that the inclusion of GnRHa depot cycle programming into a segmented ART treatment will ensure pregnancy, while significantly reducing treatment duration and cycle cancellation.

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Infant outcome of 957 singletons born after frozen embryo replacement: The Danish National Cohort Study 1995–2006

Cited by 252 publications

References 38 publications

Is IVF/ICSI with Fresh Embryo Transfer Associated with Higher Mean Singleton Birth Weight Compared to Spontaneous Conception?

Is IVF/ICSI with Fresh Embryo Transfer Associated with Higher Mean Singleton Birth Weight Compared to Spontaneous Conception?

Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles

Agonist depot versus OCP programming of frozen embryo transfer: a retrospective analysis of freeze-all cycles

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