Infant With Invasive Nontyphoidal Salmonellosis and Mastitis

Seah, Xue Fen Valerie; Ngeow, Jia Hao Alvin; Thoon, Koh Cheng; Tee, Wen Sim Nancy; Maiwald, Matthias; Chong, Chia Yin; Tan, Natalie Woon Hui

doi:10.1177/2333794x15591568

Cited by 3 publications

(4 citation statements)

References 5 publications

(12 reference statements)

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“…Typhi serovar (NCBI RefSeq number WP_053508616.1) and the fimbrial outer membrane usher StbC protein also shared its full sequence (230 aa) with that of Salmonella enterica subsp. diarizonae isolated from children (GenBank accession number JAHQRS010000001.1) [ 11 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…The fimbrial biogenesis chaperone StbB protein of S. diarizonae 58:r:z53 shared 100% of its sequence (253 aa) with that of an S. Typhi serovar (NCBI RefSeq number WP_053508616.1) and the fimbrial outer membrane usher StbC protein also shared its full sequence (230 aa) with that of Salmonella enterica subsp. diarizonae isolated from children (GenBank accession number JAHQRS010000001.1) [11,21]. In contrast, the InvF protein was truncated (216 aa) in the clinical strains referred to in [18,19], one of which caused diarrhea and sepsis with a fatal outcome (GenBank accession number CP011288.1) [19] but these proteins had 100% identity with the InvF protein of the isolate (249 aa) (Figures 7 and 8, secondary structure Figures S2 and S3) [20].…”

Section: Virulence and Pathogenic Genesmentioning

confidence: 99%

“…The fimbrial biogenesis chaperone StbB protein of S. diarizonae 58:r:z 53 shared 100% of its sequence (253 aa) with that of an S. Typhi serovar (NCBI RefSeq number WP_053508616.1) and the fimbrial outer membrane usher StbC protein also shared its full sequence (230 aa) with that of Salmonella enterica subsp. diarizonae isolated from children (GenBank accession number JAHQRS010000001.1) [11,21]. Other invasion proteins (InfE and InvG), SPI-1 type-III secretion-system export apparatus proteins (SpaP, SpaQ, and SpaS), SPI-2 type-III secretion-system apparatus proteins (SsaS, SsaR, SsaP, and SsaK), the EscJ/YscJ/HrcJ family type-III secretion innermembrane ring protein (SsaJ), the type-III secretion-system needle filament protein (SsaG), and the pathogenicity island 2 effector protein (SseG) showed 100% identity with their equivalents in clinical isolates of Salmonella diarizonae (GenBank accession numbers CP059886.1, CP123007.1, CP054422.1, and CP011288.1)…”

Section: Virulence and Pathogenic Genesmentioning

confidence: 99%

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Does Salmonella diarizonae 58:r:z53 Isolated from a Mallard Duck Pose a Threat to Human Health?

Wódz,

Piechowicz,

Tokarska-Pietrzak

et al. 2024

IJMS

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Salmonella diarizonae (IIIb) is frequently isolated from reptiles and less frequently from birds and mammals. However, its isolation from invasive human infections has not been widely reported. Migratory mallard ducks are excellent bioindicators of pathogen presence and pathogen antibiotic resistance (AMR). We present the first isolation from a mallard duck in central Europe of the antibiotic-resistant Salmonella enterica subsp. diarizonae with the unique antigenic pattern 58:r:z53 and report its whole-genome sequencing, serosequencing, and genotyping, which enabled the prediction of its pathogenicity and comparison with phenotypic AMR. The isolated strain was highly similar to S. diarizonae isolated from humans and food. Twenty-four AMR genes were detected, including those encoding aminoglycoside, fluoroquinolone, macrolide, carbapenem, tetracycline, cephalosporin, nitroimidazole, peptide antibiotic, and disinfecting agent/antiseptic resistance. Six Salmonella pathogenicity islands were found (SPI-1, SPI-2, SPI-3, SPI-5, SPI-9, and SPI-13). An iron transport system was detected in SPI-1 centisome C63PI. Plasmid profile analyses showed three to be present. Sequence mutations in the invA and invF genes were noted, which truncated and elongated the proteins, respectively. The strain also harbored genes encoding type-III secretion-system effector proteins and many virulence factors found in S. diarizonae associated with human infections. This study aims to elucidate the AMR and virulence genes in S. enterica subsp. diarizonae that may most seriously threaten human health.

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Section: Resultsmentioning

confidence: 99%

Section: Virulence and Pathogenic Genesmentioning

confidence: 99%

“…The fimbrial biogenesis chaperone StbB protein of S. diarizonae 58:r:z 53 shared 100% of its sequence (253 aa) with that of an S. Typhi serovar (NCBI RefSeq number WP_053508616.1) and the fimbrial outer membrane usher StbC protein also shared its full sequence (230 aa) with that of Salmonella enterica subsp. diarizonae isolated from children (GenBank accession number JAHQRS010000001.1) [11,21]. Other invasion proteins (InfE and InvG), SPI-1 type-III secretion-system export apparatus proteins (SpaP, SpaQ, and SpaS), SPI-2 type-III secretion-system apparatus proteins (SsaS, SsaR, SsaP, and SsaK), the EscJ/YscJ/HrcJ family type-III secretion innermembrane ring protein (SsaJ), the type-III secretion-system needle filament protein (SsaG), and the pathogenicity island 2 effector protein (SseG) showed 100% identity with their equivalents in clinical isolates of Salmonella diarizonae (GenBank accession numbers CP059886.1, CP123007.1, CP054422.1, and CP011288.1)…”

Section: Virulence and Pathogenic Genesmentioning

confidence: 99%

See 1 more Smart Citation

Does Salmonella diarizonae 58:r:z53 Isolated from a Mallard Duck Pose a Threat to Human Health?

Wódz,

Piechowicz,

Tokarska-Pietrzak

et al. 2024

IJMS

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“…Recent publications highlight the clinical importance of the presence of Salmonella enterica subsp. enterica in human milk [ 16 , 17 , 18 ]. This is an area of particular concern considering the growing use of human milk banks: specialized laboratories operating in hospitals that process milk from donors for infants who cannot be fed with their own mothers’ milk [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk

Pławińska-Czarnak

Wódz²,

Guzowska

et al. 2023

IJMS

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Salmonella is a common foodborne infection. Many serovars belonging to Salmonella enterica subsp. enterica are present in the gut of various animal species. They can cause infection in human infants via breast milk or cross-contamination with powdered milk. In the present study, Salmonella BO was isolated from human milk in accordance with ISO 6579-1:2017 standards and sequenced using whole-genome sequencing (WGS), followed by serosequencing and genotyping. The results also allowed its pathogenicity to be predicted. The WGS results were compared with the bacterial phenotype. The isolated strain was found to be Salmonella enterica subsp. enterica serovar Typhimurium 4:i:1,2_69M (S. Typhimurium 69M); it showed a very close similarity to S. enterica subsp. enterica serovar Typhimurium LT2. Bioinformatics sequence analysis detected eleven SPIs (SPI-1, SPI-2, SPI-3, SPI-4, SPI-5, SPI-9, SPI-12, SPI-13, SPI-14, C63PI, CS54_island). Significant changes in gene sequences were noted, causing frameshift mutations in yeiG, rfbP, fumA, yeaL, ybeU (insertion) and lpfD, avrA, ratB, yacH (deletion). The sequences of several proteins were significantly different from those coded in the reference genome; their three-dimensional structure was predicted and compared with reference proteins. Our findings indicate the presence of a number of antimicrobial resistance genes that do not directly imply an antibiotic resistance phenotype.

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Salmonella Breast Abscess and Salmonella Mastitis: A Review and Update of the Literature

Venyo¹

2021

CRCT

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Salmonella breast abscess / mastitis is a rare infection which can affect children and adults. It can affect females more commonly who are non-lactating and it does affect males as well as individuals who have predisposed conditions including: the immunocompromised, diabetics, rheumatoid arthritis, malignancies and other diseases. It may be acute, chronic, unilateral, or bi-lateral, as well as it may be recurrent if it is not appropriately treated. There tends to be a history of previous enteric fever (abdominal pain, vomiting, diarrhoea) which may not have been treated or adequately treated but this history has tended not to be apparent at the time of presentation. Manifestations of the disease tend to include a short- or long-history of: lump/mass in the breast which may or may not be painful, a history of previous diarrhoea, weight. The breast examination findings tend to be non-specific with some the findings including tenderness or no tenderness, a mass that may or may not be tender, a fluctuant lump that may feel like containing fluid, a firm or hard feeling lump that may mimic carcinoma of the breast. Confirmation of the diagnosis tends to be via obtaining culture and sensitivity results of a Salmonella organism and its sensitivity pattern. Treatments that have been given include: Utilization of correct antibiotics based upon the sensitivity pattern of the cultured organism, plus surgical treatment which could be complete aspiration of the pus, incision and drainage of the abscess or in cases where carcinoma of the breast was the provisional diagnosis or the diagnosis is unknown subcutaneous mastectomy and this can be avoided by biopsy of a lesion that mimics a malignant lesion. Follow up of patients is required to ensure the breast lesion has fully resolved. Adoption of the World Health organization guidelines for the prevention of Salmonella infection would help avoid the development of the infection. Urine culture, routine haematology and biochemistry blood tests as well as serology WIDAL tests and stool culture are some of the tests that tend to be undertaken in the investigation of the disease and in order to diagnose the disease a good history would be required including a history of travel from a non-typhoid endemic area to an endemic area. Conclusions: Salmonella breast abscess / mastitis is an uncommon disease which clinicians should have a high index of suspicion for. A history of previous enteric fever does help in suspecting the disease which at times does need to be distinguished from carcinoma of the breast. The diagnosis is confirmed by obtaining the culture results of the pus from the breast abscess / breast tissue. If all breast lesions are biopsied especially in cases of suspicion of a breast cancer and a past history of abdominal pain, diarrhoea and vomiting the results of the pathology examination of the specimen would negate malignancy and confirm an infection which would help in avoiding mastectomy procedures and enable utilization of antibiotics and drainage/aspiration of abscess to provide adequate treatment.

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Infant With Invasive Nontyphoidal Salmonellosis and Mastitis

Cited by 3 publications

References 5 publications

Does Salmonella diarizonae 58:r:z53 Isolated from a Mallard Duck Pose a Threat to Human Health?

Does Salmonella diarizonae 58:r:z53 Isolated from a Mallard Duck Pose a Threat to Human Health?

Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk

Salmonella Breast Abscess and Salmonella Mastitis: A Review and Update of the Literature

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