“…Decisions as to therapeutic measures covering these factors have frequently still to be made on empirical grounds. It is therefore not surprismg that instances of gross oedema are observed (Arnott and Young, 1942;Alexander, 1948). Death in infants after intravenous adminis tration of fluids has also been ascnrbed to cardiac failure due to overloading of the cirulation (Alexander, 1948).…”