Infantile digital fibromatosis‐like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings

Viale, Giuseppe; Doglioni, Claudio; Iuzzolino, P.; Bontempini, L; Colombi, R.; Coggi, Guido; Dell’Orto, Patrizia

doi:10.1111/j.1365-2559.1988.tb01956.x

Cited by 48 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The dorsal or dorsolateral aspect of the distal digit is the most frequent site, and the 2nd through 5th digits, hand and foot, are affected more often than the thumb and big toe [4,172,179,[180][181][182]. A similar proliferation has been reported after exposure to adulterated cooking oil [177,178].…”

Section: Infantile Digital Fibromamentioning

confidence: 87%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

View full text Add to dashboard Cite

Fibroblastic and myofibroblastic tumors in children and adolescents are a relatively common group of soft tissue proliferations that range from reactive to hamartomatous to neoplastic, with a full spectrum of benign, intermediate, and malignant neoplasms. These lesions are diagnostically challenging because of morphologic and immunohistochemical overlap, despite significant clinical, genetic, and prognostic differences. The fibromatoses are a major subgroup, and all types of fibromatoses can occur in the 1st 2 decades of life. Intermediate and malignant fibroblastic-myofibroblastic tumors are an important group that includes variants of fibrosarcoma and other tumors with recurrent cytogenetic or molecular genetic abnormalities and low metastatic potential. Pathologic examination is enhanced by adjunct techniques, such as immunohistochemistry, cytogenetics, and molecular genetics, although morphology provides the ultimate criteria for a specific diagnosis. This article reviews the clinicopathologic features of fibroblastic and myofibroblastic tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents, the use of diagnostic adjuncts, and differential diagnoses.

show abstract

Section: Infantile Digital Fibromamentioning

confidence: 87%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

View full text Add to dashboard Cite

show abstract

“…We do not endorse its usage for classic IDF because the presence of intracytoplasmic inclusions is not an absolute requirement for diagnosis if the clinical setting and other histologic features of the lesion are characteristic. Furthermore, similar inclusions have been identified in a number of etiopathologically diverse conditions featuring proliferating myofibroblasts 17,43,50,55,62,63,65,70,79 including intranodal myofibroblastoma, 13 endocervical polyps, 5,82 and fibroepithelial lesions of the breast, 13,36,56,60,61,73 as well as in smooth muscle tumors. 4,24,45,46,78 We agree with others that the formation of these actin-rich cytoplasmic inclusions probably represents a perturbation in the complex process of myofilament assemblage in myofibroblasts and smooth muscle cells 47,48 and by themselves are not a pathognomonic finding.…”

Section: Discussionmentioning

confidence: 80%

“…Second, case reports describing tumors with histologic features similar to those of IDF, but occurring in extradigital sites 17,50,62,65,70,79 or in the digits of adults 63 have prompted use of the alternate designation ''inclusion body fibromatosis'' 62,79,83 for these lesions and for the classic IDF. In addition, documented cases of unrelated lesions composed in part of spindled cells harboring similar cytoplasmic inclusions 4,5,13,24,36,45,46,56,60,61,78,82 raise the question of whether the IDF is truly a distinct clinicopathologic entity.…”

mentioning

confidence: 99%

Infantile Digital Fibroma/Fibromatosis

Laskin

Miettinen

Fetsch

2009

American Journal of Surgical Pathology

View full text Add to dashboard Cite

The clinicopathologic and immunohistochemical features of 69 pediatric examples of infantile digital fibroma/fibromatosis (IDF) were analyzed. Thirty males, 26 females, and 1 child (sex unstated) ranging from newborn to 120 months of age (median, 12 mo) manifested 74 lesions (5 identified in follow-up) involving the toe or finger (n=71) and the hand or foot (n=3). Tumors ranged in size from 3 to 35 (median, 10) mm. All but 4 study members presented with a solitary lesion. Metachronous IDFs developed in 7 patients within 17 to 82 months. Microscopically, a cytologically bland, fibroproliferative lesion was observed forming a dome-shaped/polypoid nodule directly beneath the epidermis and invading dermal adnexa. Mitotic figures per 20 high-powered fields ranged from 0 to 7 (median, 1). Paranuclear cytoplasmic inclusions were identified in 57 tumors. Tumor cells immunohistochemically expressed calponin (11 of 11 tumors), desmin (9/9), alpha-smooth muscle actin (11/11), CD99 (11/11), CD117 (6/8), heavy caldesmon (2/11 and scattered cytoplasmic inclusions in 4 tumors), CD10 (1/9), nuclear beta-catenin (2/11), and CD34 (1/11), but not muscle actin (HUC1-1), keratins, estrogen/progesterone receptor proteins, or activated caspase-3. Twenty-eight of 38 patients (74%) experienced recurrent/persistent disease (single in 22; multiple in 6) (median, 4 mo after surgery). One recurrent tumor spontaneously regressed and the size of another remained unchanged for almost 17 years before reexcision. All 23 patients with >5 years follow-up are currently disease free (median disease-free interval, 23 y). Minor postoperative functional/cosmetic complaints were reported in 47%. No patient with adequate clinical data developed the digitocutaneous dysplasia syndrome or a conventional fibromatosis, or relayed a family history of IDF/conventional fibromatosis. Our results indicate that IDF is a unique myofibroblastic process separable from conventional fibromatoses and from histologic mimics. Conservative excision or observation after biopsy (with additional surgery employed as necessary) are recommended treatment options.

show abstract

“…IDF rarely occurs in extra-digital sites such as the soft tissues of the arm, breast, lingual, and thigh. [6–11] Fernández-Jorge et al . [12] reported that magnetic resonance image displayed a fibromatous tumor, which locally infiltrated tendon structures.…”

Section: Discussionmentioning

confidence: 99%

Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement

et al. 2013

View full text Add to dashboard Cite

A 9-day-old male baby was hospitalized after his birth due to some swells under the skin. The hard consistency nodules observed under the skin all over the body of the patient were of different size, and presented lesions, among which the biggest was 1 × 1 cm. No lesions were observed on the fingers. By superficial ultrasonography, multiple isoechoic hypoechoic lesions were observed among the muscle plan. In thoracolumbar magnetic resonance imaging, multiple massif lesions retaining peripheral contrast (the biggest was 1.7 × 1.4 cm large) had been observed under the skin muscle plans, between the muscles of the extremities. The biopsy was positive for smooth muscle actin, but negative for desmin, S100, and CD34. These findings were diagnosed as infantile digital fibromatosis (IDF) (inclusion body fibromatosis). The case was presented with an objective to illustrate and remind that IDF can be observed in babies without finger involvement.

show abstract

Infantile digital fibromatosis‐like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings

Cited by 48 publications

References 17 publications

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

Infantile Digital Fibroma/Fibromatosis

Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement

Contact Info

Product

Resources

About