Infantile Hemangiomas and Retinopathy of Prematurity: Possible Association

Vijayakumar, Praveen; Vidavalur, Ramesh; Rosenkrantz, Ted S.; Hussain, Naveed

doi:10.1542/peds.2007-0803

Cited by 55 publications

(35 citation statements)

References 32 publications

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“…The positive results of these experiments (8-10), confirmed also in mice with choroidal neovascularization (21), prompted us to extend this experimentation to newborns with a precocious stage of ROP as well as (22) a clinical condition driven by high levels of VEGF and frequently associated with IHs (23).…”

Section: Discussionmentioning

confidence: 92%

Pharmacokinetics and local safety profile of propranolol eye drops in rabbits

et al. 2014

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Background: Oral propranolol, a nonselective β-blocker, is able to reduce the progression of retinopathy of prematurity in newborns, but it appeared unsafe. This study aimed to find, in rabbits, a propranolol eye drop concentration able to induce lower plasma but higher retinal concentrations than those obtained after oral administration. Methods: Male New Zealand white rabbits were treated with oral propranolol (0.25 mg/kg/6 h) for 5 d, and propranolol concentrations were measured after 1, 2, 3, and 6 h in plasma, aqueous humor, vitreous humor, and retina. These concentrations were compared with those obtained after the administration of one drop of 25 μl of propranolol 0.1% prepared in saline, applied every 6 h to both eyes for 5 d. A Draize eye test and histological analyses were performed to assess eye drop tolerability. results: The administration of eye drops produced retinal concentrations similar to, but plasma concentrations significantly lower than, those measured after oral administration. The local tolerability profile was excellent. conclusion: Propranolol eye drops are able to ensure high retinal and low plasma concentrations of propranolol, and this finding opens the perspective of possible topical treatment with propranolol in newborns with retinopathy of prematurity.

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Section: Discussionmentioning

confidence: 92%

Pharmacokinetics and local safety profile of propranolol eye drops in rabbits

et al. 2014

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“…(12) Another supportive finding is the association of IH with retinopathy of prematurity, a condition known to be linked to ischemia. (19) GLUT-1, present on IH tissue, is a facilitative glucose transporter that is an important sensor for hypoxia. (20) The growth of IH likely involves angiogenic peptides, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor, which induce proliferation of blood vessels.…”

Section: Pathophysiology:-mentioning

confidence: 99%

Current Concepts in the Pathogenesis and Management of Vascular Lesions - A Brief Review.

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2017

IJAR

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“…This pattern is reminiscent of the natural history of retinopathy of prematurity (ROP) which is absent during the first 4-6 weeks of life, followed by a phase of rapid vessel proliferation and sequential gradual resolution [13,14] . Infantile hemangiomas are more common in very preterm infants, as opposed to term infants, and there is an association between infantile hemangioma and ROP [15] . The clinical similarities of infantile hemangioma and ROP and the successful treatment of infantile hemangiomas with oral propranolol have prompted experiments with various mouse strains investigating the effects of propranolol on oxygen-induced retinopathy which bears many hallmarks of ROP.…”

Section: Infantile Hemangioma and Retinopathy Of Prematuritymentioning

confidence: 99%