Infantile Hemangiomas in Twins: A Prospective Cohort Study

Greco, Margaret; Frieden, Ilona J.; Drolet, Beth A.; Garzon, María C.; Mancini, Anthony J.; Chamlin, Sarah L.; Metry, Denise; Adams, Denise M.; Lucky, Anne W.; Wentzel, Mary Sue; Horii, Kimberly A.; Baselga, Eulàlia; McCuaig, Catherine; Powell, Julie; Haggstrom, Anita N.; Siegel, Dawn H.; Morel, Kimberly D.; Cordisco, Maria; Nopper, Amy J.; Krol, Alfons

doi:10.1111/pde.12781

Cited by 18 publications

(20 citation statements)

References 16 publications

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“…10,29 Studies comparing IH in monozygotic and dizygotic twins found no evidence of zygosity as a risk factor. 12,14 We detected 2 concordant monozygotic sets of twins and 1 discordant monozygotic twin but only 1 concordant dizygotic set of twins. The low number of twins in our study prevents drawing further conclusions.…”

Section: Discussionmentioning

confidence: 82%

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Inheritance Patterns of Infantile Hemangioma

et al. 2016

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Section: Discussionmentioning

confidence: 82%

“…Familial clustering has been reported, even though genetic predisposition is controversial. 6,7,10,[12][13][14] Evidence exists that some IHs are inherited. Using information from the Utah Population Database, Grimmer et al 15 reported a twofold increase in the risk ratio for hemangioma among siblings of an affected proband.…”

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confidence: 99%

Inheritance Patterns of Infantile Hemangioma

et al. 2016

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“…Monozygotic twins also did not present an increased incidence of hemangioma within their own group, which shows that hereditary factors are not dominant factors in development of hemangioma and that hemangioma is more common among twin pairs with lower birth weight. 24 The retrospective nature of our study is a major limitation to detect the real frequency of the probable factors causing hemangioma. Authors of the study are in the opinion that there is a need for more extensive prospective research work to be done in this field to conclude that these factors constitute an absolute risk for development of hemangioma.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological features and risks of hemangiomas

2017

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Şahin G, Düzcan-Kilimci D, Tanyıldız HG. Epidemiological features and risks of hemangiomas. Turk J Pediatr 2017; 59: 664-669. Hemangiomas are the most common benign tumors of childhood. The known risk factors in developing hemangiomas are female gender, prematurity and low birth weight. Our study was designed to investigate prenatal and natal risk factors in addition to the above factors that would potentially affect development of hemangiomas. Two hundred forty hemangioma patients and 100 healthy controls were included in the study. Both groups were interviewed for age, gender, prenatal characteristics (presence of maternal pregnancy hypotension, hypertension and hyperemesis, parental smoking habits) as well as natal characteristics (delivery, birth weight, gestational age) and maternal-paternal age. Hemangiomas were mostly localized in the head and neck. Risk of developing hemangioma was higher in girls and in firstlings. History of hyperemesis during pregnancy increased incidence of hemangioma. Post-term delivery was found to be protective against developing hemangioma. We are in the opinion that there is a need for wider studies with a bigger sample size so as to detect other risk factors.

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“…Yüzonsekiz ikiz eşi üzerinde yapılan bir çalışmada, monozigotik ve dizigotik ikizlerde hemanjiom insidansı arasında fark bulunmamıştır. Bu da kalıtsal faktörlerin hemanjiom gelişiminde etkili dominant faktörler olmadığını göstermektedir (29).…”

Section: Bulgularunclassified

Konjenital Hemanjiomlarin Ozellikleri

2018

GMJ

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Hemanjiomlar çocukluk çağının en sık görülen benign tümörleridir. Bilinen risk faktörleri kız cinsiyet, prematürite ve düşük doğum ağırlığıdır. Bu çalışmada bu faktörlere ek olarak hemanjiom gelişimini etkileyebilecek prenatal ve natal risk faktörlerinin araştırılması planlandı. Çalışmaya 114 konjenital hemanjiomlu hasta ve 100 sağlıklı çocuk dahil edildi. İki grubun yaş, cinsiyet, prenatal özellikleri (annenin gebelikte ilaç kullanımı, gebelikte geçirdiği hastalıklar, annede gebelikte hipo-hipertansiyon ve hiperemezis varlığı, anne ve babanın sigara kullanımı), natal özellikleri (doğum şekli, doğum ağırlığı, gestasyon yaşı), anne-baba yaşı, anne-baba hastalıkları ve kullandığı ilaçlar sorgulandı. Konjenital hemanjiomların en sık yerleşim yeri baş-boyun bölgesi idi. Kız olmak ve birinci çocuk olmak konjenital hemanjiom gelişim riskini artırıyordu. Annenin gebeliğinde hiperemezis öyküsünün olması konjenital hemanjiom gelişim riskini 1.75 kat artırıyordu. Postterm ve 4000 gramın üzerinde doğum konjenital hemanjiom gelişimine karşı koruyucu idi. Bilinen risk faktörlerinin dışında gebelikte ilaç kullanımının da konjenital hemanjiom gelişimi için bir risk faktörü olabileceği tespit edildi. İleride konuyla ilgili yapılacak çalışmaların daha geniş hasta gruplarında yapılmasını ve daha farklı risk faktörlerinin de göz önünde bulundurulmasını öneriyoruz.

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Infantile Hemangiomas in Twins: A Prospective Cohort Study

Abstract: These findings suggest that the origin of IHs is multifactorial and that predisposing factors such as birthweight, sex, and GA may interact with one another such that a threshold is reached for clinical expression.

Cited by 18 publications

References 16 publications

Inheritance Patterns of Infantile Hemangioma

Inheritance Patterns of Infantile Hemangioma

Epidemiological features and risks of hemangiomas

Konjenital Hemanjiomlarin Ozellikleri

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