Infantile Myofibromatosis

Abstract

Infantile myofibromatosis is a mesenchymal disorder characterized by the fibrous proliferation of the skin, bone, muscle and viscera. It is the most common fibrous tumor in childhood. We present a newborn with skin and bone disease without visceral involvement, who showed good response to vinblastine and methotrexate. Clinical features, etiology, diagnosis, and treatment are reviewed.

Enlarging ulcerated nodule on the hand of a child

“…Thus, the initial treatment option for many patients is conservative observation and patient education. 10 In cases with progressing, visceral, or symptomatic lesions, surgical excision is the main option for treatment. In about 10% of cases, lesions recur after removal.…”

“…With the possibility of spontaneous regression, therapeutic abstention has been suggested in sites where surgery may harm the patient's appearance or function. Thus, the initial treatment option for many patients is conservative observation and patient education 10 . In cases with progressing, visceral, or symptomatic lesions, surgical excision is the main option for treatment.…”