Infantile myofibromatosis of the triceps detected by prenatal sonography

Kubota, Akio; Imano, Motohiro; Yonekura, Takeo; Hirooka, Shinji; Nose, Keisuke; Oyanagi, Harumasa; Nakayama, Masahiro

doi:10.1002/(sici)1097-0096(199903/04)27:3<147::aid-jcu8>3.0.co;2-c

Cited by 25 publications

(16 citation statements)

References 12 publications

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“…Other soft-tissue tumors that present in the fetal-neonatal period with a hypervascular appearance include infantile myofibromatosis and congenital infantile fibrosarcoma [29,30]. However these tumors have not been described in association with cardiomegaly or congestive heart failure.…”

Section: Discussionmentioning

confidence: 99%

Imaging evaluation of fetal vascular anomalies

et al. 2014

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Vascular anomalies can be detected in utero and should be considered in the setting of solid, mixed or cystic lesions in the fetus. Evaluation of the gray-scale and color Doppler US and MRI characteristics can guide diagnosis. We present a case-based pictorial essay to illustrate the prenatal imaging characteristics in 11 pregnancies with vascular malformations (5 lymphatic malformations, 2 Klippel-Trenaunay syndrome, 1 venous-lymphatic malformation, 1 Parkes-Weber syndrome) and vascular tumors (1 congenital hemangioma, 1 kaposiform hemangioendothelioma). Concordance between prenatal and postnatal diagnoses is analyzed, with further discussion regarding potential pitfalls in identification.

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Section: Discussionmentioning

confidence: 99%

Imaging evaluation of fetal vascular anomalies

et al. 2014

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“…The incidence of soft tissue tumors in newborns is low and is approximately 1/150 000 [5]. Nevertheless, IM comprises 35% of the soft tissue tumors presented at the time of birth with an incidence in newborns of 1/400 000 [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, IM comprises 35% of the soft tissue tumors presented at the time of birth with an incidence in newborns of 1/400 000 [5,6]. IM is characterized by a variety of nodular forms in soft tissue, bone, and the visceral organs [1].…”

Section: Discussionmentioning

confidence: 99%

“…Although IM is an extremely rare benign tumor-disease, it manifests as the most common fibrous tumor in the first year of life [2][3][4][5][6]. Four types of IM have been categorized: (i) solitary, (ii) multicentric with single visceral involvement, (iii) multicentric with multiple visceral involvements, and (iv) multicentric without visceral involvement.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of infantile myofibromatosis and review of literature

Hausbrandt

Leithner

Beham

et al. 2010

Journal of Pediatric Orthopaedics B

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Infantile myofibromatosis is a rare benign tumor-disease (1/400,000). Four different types have been reported in literature. The most commonly affected body areas are the head, the neck, and the trunk. We would like to present a rare case of a multicentric type with singular visceral involvement and a literature review of all case series with more than five patients. A 9-month-old boy presented with a swelling on the medial side of his proximal left tibia. The lesion which was present since birth, was well palpable, indolent, hard, and mobile in relation to the surrounding tissue. Radiographic films and ultrasound examination presented a pretibial soft-tissue tumor mass with calcifications and two osteolytic lesions with a sclerotic rim. A skeletal survey showed more osteolytic lesions, but the magnetic resonance imaging showed no more soft-tissue lesions. The rapid frozen section biopsy hinted at the diagnosis of histiocytosis X. The definitive histological result 6 days later was infantile myofibromatosis. As therapy, we determined a wait-and-see policy with controls all 3 months. At 20 months follow-up, the boy showed beginning of regression of all lesions. Infantile myofibromatosis is a very rare benign tumor-disease. Radiologically often soft-tissue masses with calcifications and osteolytic lesions with sclerotic rims are described. These findings also can be interpreted as histiocytosis X, which is a potential differential diagnosis. Histopathologically, cells characteristically appear as spindle-shaped fibroblast cells with pale pink cytoplasm and elongated nuclei and the immunophenotype is defined with a positive reaction on smooth-muscle antigen vimentin and the muscle-specific antigen HHF-35. The data of the literature review underline that a wait-and-see-policy should be considered as the first treatment of choice as in most instances the bony lesions regress spontaneously. However, a thorough examination has to be carried out to exclude lesion in other organs like gastro-intestinal or cardio-pulmonary nodular tumor masses. In conclusion, the present case report and the literature review support the notion that infantile myofibromatosis should be considered as a possible differential diagnosis for soft tissue expansions and/or osteolytic lesions in a newborn.

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“…A review of the literature revealed three cases of infantile myofibromatosis suspected at ultrasound scan, which were later confirmed by histological diagnosis. Kubota et al [6] reported, in 1999, the first prenatal sonographic detection of infantile myofibromatosis in the triceps at 36 weeks of gestation. The same year, Nishioka et al [9], described a sonographic suspicion of the disease at 37 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

Multicentric infantile myofibromatosis: two perinatal cases

et al. 2006

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Infantile myofibromatosis, the most common fibrous tumor of infancy, occurs in solitary, multiple, and generalized forms, with similar histology but different clinicopathologic and prognostic implications. This entity is a mesenchymal disorder characterized by the proliferation of fibrous tumors in the skin, muscles, viscera, bones, and subcutaneous tissues. Visceral lesions are associated with significant morbidity and mortality, generally within the first few months of life. They lead to failure to thrive, to infection, hemorrhage, or to the obstruction of vital organs. We describe two cases of multicentric myofibromatosis with significant in utero lesional growth, resulting in one fetal demise and one post-natal demise. To the best of our knowledge, this is the first report of a fetal death secondary to infantile myofibromatosis.

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Infantile myofibromatosis of the triceps detected by prenatal sonography

Cited by 25 publications

References 12 publications

Imaging evaluation of fetal vascular anomalies

Imaging evaluation of fetal vascular anomalies

A rare case of infantile myofibromatosis and review of literature

Multicentric infantile myofibromatosis: two perinatal cases

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