Infantile myofibromatosis: unusual diagnosis in an older child

Franzese, Christine B.; Carron, Jeffrey D.

doi:10.1016/j.ijporl.2005.01.021

Cited by 13 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En el año 2005, un caso descrito como miofibromatosis infantil fue descrito con una lesión solitaria erosionando la eminencia cigomática recubierta por una cápsula aparentemente derivada del periostio; sin embargo, se reporta que esta lesión se disecó fácilmente del hueso adyacente, radiográficamente se muestra de características similares al caso presentado en nuestro trabajo, una masa de tejido blando homogéneo con erosión ósea de la pared anterior del seno maxilar. 34 Algunos autores creen que en edades tempranas puede existir regresión de esta lesión 5,23 mientras que otros refutan esta teoría, 22 también el miofibroma puede desarrollarse durante la vía intrauterina y Aunque se han propuesto diversas causas para el miofibroma, la realidad es que su causa exacta aún es desconocida, algunos estudios proponen un origen a partir de restos de miopericitos y células mesenquimales perivasculares, pero no sustentan la reactividad de las mismas en el rol de estas neoplasias. 4 En realidad, existen pocos casos reportados de miofibroma mandibular bien descritos en la literatura, únicamente 39 hasta el momento, en los cuales es frecuente encontrar asociación a algún folículo u órgano dental, 1 lo cual refuerza la teoría de un posible origen odontogénico cuando se manifiesta en la región mandibular.…”

Section: Discussionunclassified

Miofibroma mandibular periosteal sin componente intraóseo: presentación de un caso en paciente pediátrico

Bello¹,

Salgado²,

Balandrano³

2020

Revista Mexicana De Cirugía Bucal Y Maxilofacial

View full text Add to dashboard Cite

Introducción: El miofibroma es una lesión neoplásica benigna de células miofibroblásticas de rara aparición en la región maxilofacial, se considera una patología homóloga en solitario de la miofibromatosis que ocurre cuando se identifican múltiples lesiones en un mismo paciente. Objetivo: Se presenta una variedad clínica periosteal no descrita previamente en la literatura del miofibroma mandibular en un paciente pediátrico. Presentación del caso: Se reporta un caso de siete años de evolución en un paciente femenino recibido a los tres años con diagnóstico de miofibroma mandibular periosteal tratada con la enucleación del tumor y la resección del borde óseo mandibular afectado, también se describen los aspectos clínicos, radiográficos e histopatológicos relevantes al manejo y tratamiento de esta enfermedad. Conclusiones: Es importante documentar casos clínicos de características particulares, en lesiones controversiales de difícil diagnóstico para evitar procedimientos agresivos innecesarios.

show abstract

Section: Discussionunclassified

Miofibroma mandibular periosteal sin componente intraóseo: presentación de un caso en paciente pediátrico

Bello¹,

Salgado²,

Balandrano³

2020

Revista Mexicana De Cirugía Bucal Y Maxilofacial

View full text Add to dashboard Cite

show abstract

“…Imaging is usually obtained to determine the extent of disease progression or regression and to look for recurrence. 13 CT typically shows a nonhomogeneous mass with distinct borders; with contrast enhancement, CT shows variability in the enhancement pattern. Intratumoral calcifi cations and possible zones of necrosis may also be noted.…”

Section: Discussionmentioning

confidence: 99%

Myofibroma of the Zygomatic Bone in an Older Child: A Case Report

Acıoğlu¹,

Acar

Alimoğlu

et al. 2011

Ear Nose Throat J

View full text Add to dashboard Cite

Myofi broma/myofi bromatosis is a rare mesenchymal disorder that is part of a heterogeneous group of approximately 20 disorders that are classifi ed primarily according to the proliferation of benign fi brous elements. Th ese lesions can arise during a wide range of ages, with many occurring in the fi rst decade of life, and they are slightly more common in males than females. Th e etiology of this disease is not well understood. Clinically, patients with myofi broma/myofi bromatosis present with various signs, ranging from superfi cial, cutaneous, purplish macules to freely movable subcutaneous masses to deep-seated fi xed lesions. Th e defi nitive diagnosis is made on histopathologic grounds. Th e destructive clinical behavior of myofi broma/ myofi bromatosis in the setting of insuffi cient pre-or perioperative diagnostic evaluations (e.g., a failure to perform fi ne-needle aspiration or frozen-section biopsy) may guide the clinician toward a radical surgical procedure rather than a simple excision.

show abstract

“…They also stated that although 53% of patients manifested with the solitary type, 92% were found to be affected with the multicentric type. Although there are just a few reports of IM in older patients [8], publications have emerged recognizing the detection of IM in utero [5,9]. The etiology and the genesis of IM are not clear, although IM has been reported as an autosomal dominant condition [10,11].…”

Section: Discussionmentioning

confidence: 99%

A rare case of infantile myofibromatosis and review of literature

Hausbrandt

Leithner

Beham

et al. 2010

Journal of Pediatric Orthopaedics B

View full text Add to dashboard Cite

Infantile myofibromatosis is a rare benign tumor-disease (1/400,000). Four different types have been reported in literature. The most commonly affected body areas are the head, the neck, and the trunk. We would like to present a rare case of a multicentric type with singular visceral involvement and a literature review of all case series with more than five patients. A 9-month-old boy presented with a swelling on the medial side of his proximal left tibia. The lesion which was present since birth, was well palpable, indolent, hard, and mobile in relation to the surrounding tissue. Radiographic films and ultrasound examination presented a pretibial soft-tissue tumor mass with calcifications and two osteolytic lesions with a sclerotic rim. A skeletal survey showed more osteolytic lesions, but the magnetic resonance imaging showed no more soft-tissue lesions. The rapid frozen section biopsy hinted at the diagnosis of histiocytosis X. The definitive histological result 6 days later was infantile myofibromatosis. As therapy, we determined a wait-and-see policy with controls all 3 months. At 20 months follow-up, the boy showed beginning of regression of all lesions. Infantile myofibromatosis is a very rare benign tumor-disease. Radiologically often soft-tissue masses with calcifications and osteolytic lesions with sclerotic rims are described. These findings also can be interpreted as histiocytosis X, which is a potential differential diagnosis. Histopathologically, cells characteristically appear as spindle-shaped fibroblast cells with pale pink cytoplasm and elongated nuclei and the immunophenotype is defined with a positive reaction on smooth-muscle antigen vimentin and the muscle-specific antigen HHF-35. The data of the literature review underline that a wait-and-see-policy should be considered as the first treatment of choice as in most instances the bony lesions regress spontaneously. However, a thorough examination has to be carried out to exclude lesion in other organs like gastro-intestinal or cardio-pulmonary nodular tumor masses. In conclusion, the present case report and the literature review support the notion that infantile myofibromatosis should be considered as a possible differential diagnosis for soft tissue expansions and/or osteolytic lesions in a newborn.

show abstract

Infantile myofibromatosis: unusual diagnosis in an older child

Cited by 13 publications

References 14 publications

Miofibroma mandibular periosteal sin componente intraóseo: presentación de un caso en paciente pediátrico

Miofibroma mandibular periosteal sin componente intraóseo: presentación de un caso en paciente pediátrico

Myofibroma of the Zygomatic Bone in an Older Child: A Case Report

A rare case of infantile myofibromatosis and review of literature

Contact Info

Product

Resources

About