Infantile scoliosis in Beals syndrome: the use of a non-fusion technique for surgical correction

Martin, Anthony G; Foguet, Pedro; Marks, David; Thompson, A. G.; Child, A. H.

doi:10.1007/s00586-005-0980-9

Cited by 10 publications

(4 citation statements)

References 19 publications

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“…5,35,36 The observed increase in ROM with discectomy (Figure 2) substantiates the notion that ROM relies heavily on the quantity of functional NP. 19 In the sham control group, ROM appears to continually increase from its initial discectomy ( p > 0.05 compared to discectomy). It is hypothesized that further cyclic loading in the discectomy group with no implant would lead to increased ROM from fatigue damage.…”

Section: Discussionmentioning

confidence: 87%

An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc

Malhotra

Han²,

Beckstein³

et al. 2012

Spine

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Study Design Investigation of injectable nucleus pulposus (NP) implant. Objective To assess the ability of a recently developed injectable hydrogel implant to restore non-degenerative disc mechanics through support of NP functional mechanics. Summary of Background Data While surgical intervention for low back pain is effective for some patients, treated discs undergo altered biomechanics and adjacent levels are at increased risk for accelerated degeneration. One potential treatment as an alternative to surgery for degenerated disc includes the percutaneous delivery of agents to support NP functional mechanics. The implants are delivered in a minimally invasive fashion, potentially on an outpatient basis, and do not preclude later surgical options. One of the challenges in designing such implants include the need to match key NP mechanical behavior and mimic the role of native non-degenerate NP in spinal motion. Methods The oxidized hyaluronic acid gelatin implant material was prepared. In vitro mechanical testing was performed in mature ovine bone-disc-bone units in three stages: intact, discectomy, and implantation vs. sham. Tested samples were cut axially for qualitative structural observations. Results Discectomy increased axial range of motion (ROM) significantly compared to intact. Hydrogel implantation reduced ROM 17% (p < 0.05) compared to discectomy and returned ROM to intact levels (ROM intact 0.71 mm, discectomy 0.87 mm, post-implantation 0.72 mm). While ROM for the hydrogel implant group was statistically unchanged compared to the intact disc, ROM for sham discs, which received a discectomy and no implant, was significant increase compared to intact. The compression and tension stiffness were decreased with discectomy and remained unchanged for both implant and sham groups, as expected because the annulus fibrosus was not repaired. Gross morphology images confirmed no ejection of NP implant. Conclusion An injectable implant that mimics non-degenerate NP has the potential to return motion segment ROM to normal subsequent to injury.

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Section: Discussionmentioning

confidence: 87%

An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc

Malhotra

Han²,

Beckstein³

et al. 2012

Spine

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“…In general, it has a triple-helix structure, forms a highly organized 3D architecture, and plays a crucial role in maintaining the biological and structural integrity of the ECM ( Cen et al, 2008 ; da Silva Morais et al, 2020 ). Since collagen is the main component of hard tissues and fibrous tissue and has excellent biocompatibility and degradability and low antigenicity, a large number of tissue engineering studies have utilized it in scaffolds for orthopedic applications, such as those in bone ( Sarkar et al, 2006 ), cartilage ( Zhang et al, 2013 ), tendons ( Caliari et al, 2011 ), and intervertebral discs ( Wilke et al, 2006 ). Collagen is widely used in the construction of meniscal cartilage tissue engineering scaffolds in various manufacturing methods.…”

Section: Polymers For Meniscal Tissue Engineering Applicationsmentioning

confidence: 99%

Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications

Yang

et al. 2021

Front. Cell Dev. Biol.

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Knee menisci are structurally complex components that preserve appropriate biomechanics of the knee. Meniscal tissue is susceptible to injury and cannot heal spontaneously from most pathologies, especially considering the limited regenerative capacity of the inner avascular region. Conventional clinical treatments span from conservative therapy to meniscus implantation, all with limitations. There have been advances in meniscal tissue engineering and regenerative medicine in terms of potential combinations of polymeric biomaterials, endogenous cells and stimuli, resulting in innovative strategies. Recently, polymeric scaffolds have provided researchers with a powerful instrument to rationally support the requirements for meniscal tissue regeneration, ranging from an ideal architecture to biocompatibility and bioactivity. However, multiple challenges involving the anisotropic structure, sophisticated regenerative process, and challenging healing environment of the meniscus still create barriers to clinical application. Advances in scaffold manufacturing technology, temporal regulation of molecular signaling and investigation of host immunoresponses to scaffolds in tissue engineering provide alternative strategies, and studies have shed light on this field. Accordingly, this review aims to summarize the current polymers used to fabricate meniscal scaffolds and their applications in vivo and in vitro to evaluate their potential utility in meniscal tissue engineering. Recent progress on combinations of two or more types of polymers is described, with a focus on advanced strategies associated with technologies and immune compatibility and tunability. Finally, we discuss the current challenges and future prospects for regenerating injured meniscal tissues.

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“…Contractures of the digits and folded ears are additional hallmarks of the disorder. Earlyonset scoliosis may occur and can be managed according to the principles above [26].…”

Section: Marfan Syndromementioning

confidence: 99%

Connective Tissue Syndromes: Themes and Guidelines for the Spine Deformity Surgeon

Tan

Sponseller

2012

Spine Deformity

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Infantile scoliosis in Beals syndrome: the use of a non-fusion technique for surgical correction

Cited by 10 publications

References 19 publications

An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc

An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc

Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications

Connective Tissue Syndromes: Themes and Guidelines for the Spine Deformity Surgeon

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