Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex

Goh, Suzanne; Kwiatkowski, David J.; Dorer, David J.; Thiele, Elizabeth A.

doi:10.1212/01.wnl.0000168908.78118.99

Cited by 136 publications

(104 citation statements)

References 10 publications

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“…Others have shown that control of infantile spasms is associated with better development during infancy and childhood [4], [6], [10], [12], [22], [23], [24] and [25]. In a previous report [11], more frequent spasms in children undergoing early surgical intervention were documented.…”

Section: Discussionmentioning

confidence: 99%

Longer duration of epilepsy and earlier age at epilepsy onset correlate with impaired cognitive development in infancy

Vendrame

Alexopoulos

Boyer

et al. 2009

Epilepsy & Behavior

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We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3 years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with epilepsy. Developmental quotients were calculated and were correlated with age at epilepsy onset, duration of epilepsy, seizure frequency, brain pathology, and types of seizures (with/without spasms) as potential predictors. Infants with longer duration and earlier onset of epilepsy performed worse on developmental neuropsychological testing. Regression analyses showed that age at epilepsy onset and percentage of life with epilepsy were both strongly associated (regression model P < 0.0001) with developmental quotient. There was no correlation with seizure frequency. Infants with spasms had worse developmental quotients than infants without spasms (P < 0.001). These results suggest that duration of epilepsy and age at onset may be the best developmental predictors during the first years of life in patients with epilepsy. Early aggressive intervention should be considered.

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Section: Discussionmentioning

confidence: 99%

Longer duration of epilepsy and earlier age at epilepsy onset correlate with impaired cognitive development in infancy

Vendrame

Alexopoulos

Boyer

et al. 2009

Epilepsy & Behavior

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“…количество туберов наряду с их двусторонним распо-ложением и локализацией в височных долях являет-ся еще одним фактором риска [25,29,36,42,52,67,70]. Однако есть пациенты с ТС и нормальным пси-хическим статусом, несмотря на высокое число тубе-ров -это пациенты без эпилепсии или с хорошо контролируемыми эпилептическими приступами [40].…”

Section: детской неврологииunclassified

“…Факторы риска расстройств аутистического спек-тра у пациентов с ТС значительно совпадают с факто-рами риска умственной отсталости [5,25,44,51]. К со-жалению, ожидания, что пациенты с ТС избавятся также от проявлений расстройств аутистического спектра после успешного хирургического лечения эпилепсии (с точки зрения контроля над приступами), должны быть менее оптимистичными.…”

Section: детской неврологииunclassified

Epilepsy Surgery in Patients With Tuberous Sclerosis

Holthausen¹,

Pieper²,

Eitel³

et al. 2015

Rus. ž. det. nevrol.

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“…There are reports suggesting benefit from regular cranial imaging to screen for SEGAs. 42,43 The expert panel at the TS Consensus Conference in 1998 concluded that early detection and treatment increased the chances of complete excision and recommended CT or MRI scanning every 1 -3 years in children and less often in adults. 35 This has not been universally adopted and more studies are needed to determine the value of screening and the criteria for surgical intervention.…”

Section: Managementmentioning

confidence: 99%