Infantile tremor syndrome

Puttagunta, Apoorva Sree; Shruthi, T K; Shubha, S; Rajakumar, Perumal

doi:10.18203/2349-3291.ijcp20174763

Cited by 2 publications

(4 citation statements)

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“…7 Corresponding with our study, low maternal serum vitamin B12 levels act as surrogate marker of infantile vitamin B12 deficiency. 1,7 Inconclusive data are also favouring deficiencies of zinc, magnesium and calcium. 1,8 There are three stages of ITS on the basis of history, physical examination and follow up.…”

Section: Discussionmentioning

confidence: 99%

“…Limb muscles are usually flabby to feel, however, there is presence of extrapyramidal type of rigidity on passive movements. 1 Neuroimaging in ITS shows non-specific cerebral atrophy, dilatation of ventricles and prominence of extra cerebral spaces. 2 There is a possibility that these scans can revert back to normal on follow up after proper nutritional rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

“…ITS is a clinical state characterized by tremors, anemia, pigmentary skin, regression of mental development and hypotonia of muscles. 1 Exact incidence of infantile tremor syndrome in general population is not known, but ITS has accounted for 0.77-2.5% of the pediatric ward admissions. Very likely, clinically encountered ITS cases represent only 'tip-of-the-iceberg', with vast majority of asymptomatic cases remaining under-recognised.…”

Section: Introductionmentioning

confidence: 99%

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Clinical profile of patients with infantile tremor syndrome in a tertiary care center

Pathak

Chauhan

Pandya

2020

Int J Contemp Pediatr

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Background: Infantile tremor syndrome (ITS) is a condition reported from many areas of Indian subcontinent due to lack of proper nutrition, improper weaning or delayed introduction of complementary feeding. There is no proven macro or micro nutrient deficiency responsible for it but relation with vitamin B12 deficiency has been identified in some studies. The aim of this study was to study the clinical profile of patients with ITS.Methods: It is a prospective observational study including total 30 patients, from 6 months to 3-year age group, admitted to pediatric wards and nutritional rehabilitation centre, civil hospital, Ahmedabad, from June 2018 to December 2019.Results: Out of 30 patients studied, 69% had pre-ITS and rest had ITS, 61.5% were males and 38.4% were females, 69.2% had severe acute malnutrition, 84.6% had severe anemia and 23% of them presented with CCF, 15.4% patients had microcephaly and 23% had hypotonia. 23% had motor and speech delay. 61.5% belonged to lower socio-economic group. There was delayed introduction of complementary feeding in 63% of patients. 69% patients had severe vitamin B12 deficiency and 21% had moderate vitamin B12 deficiency.Conclusion: ITS, is commonly seen among male children belonging to lower socio-economic group among age group of 6 months to 24 months, presents with coarse tremors with moderate to severe anemia with moderate to severe acute malnutrition and is associated with deficiency of vitamin B12. Early diagnosis and treatment including nutritional rehabilitation grossly improved the outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical profile of patients with infantile tremor syndrome in a tertiary care center

Pathak

Chauhan

Pandya

2020

Int J Contemp Pediatr

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“…[1][2][3] High protein diet, multivitamins, folic acid, iron, calcium, zinc and magnesium has been the choice of treatment for nutritional deficient individuals. 4…”

Section: Introductionmentioning

confidence: 99%