Infantile Wernicke's encephalopathy

Qureshi, Umar Amin; Wani, Nisar Ahmad; Ahmad, Kaisar; Irshad, Muhammad; Ali, Iram

doi:10.1136/archdischild-2014-307949

Cited by 16 publications

(13 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, infantile encephalitic beriberi in a chronic thiamine deficiency state may evolve as a differential injury pattern with the highly active basal ganglia being affected by toxic metabolites or energy depletion and the vital brainstem and hypothalamus spared [1,19]. Distinct basal ganglia predominant or brainstem/hypothalamic/thalamic predominant MR patterns may also result when there is thiamine deficiency within cells (intracellular thiamine deficiency) resulting from mutation of the gene encoding thiamine transporter protein [20,21].…”

Section: Discussionmentioning

confidence: 99%

Infantile encephalitic beriberi: magnetic resonance imaging findings

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Infantile encephalitic beriberi: magnetic resonance imaging findings

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Some children with beriberi and adults with Wernicke's encephalopathy display similar brain changes on magnetic resonance imaging, specifically, bilateral, symmetric hyperintensity signals in the mammillary bodies, thalamic, and periaqueductal areas; however, pediatric brain neuroimaging may also show lesions in the basal ganglia and the frontal lobes. In a recent study of infants with thiamine deficiency encephalopathies, cranial ultrasound revealed hyperechoic lesions of the basal ganglia …”

Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 98%

“…Beriberi in older infants and children may present with predominant neurological symptoms, including loss of appetite, nystagmus, ophthalmoplegia, bulging fontanelle, and loss of consciousness . In areas with low awareness of thiamine deficiency, symptoms are easily mistaken for meningitis.…”

Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 99%

“…A number of reports of infantile beriberi have emerged from the northern region of India, where the diet consists largely of polished, unfortified rice . Cases all occurred in infants who were exclusively breastfed, and the majority of mothers followed a customary dietary restriction.…”

Section: Prevalence Of Thiamine Deficiency and Burden Of Tddsmentioning

confidence: 99%

“…For example, India, a large country with a diverse population, is not identified by FBS data as a country with thiamine deficiency. However, infantile beriberi cases have been reported in recent years in the northern region of Kashmir, where diets consist largely of polished rice . The ability to disaggregate dietary data for specific population subgroups can be useful in assessing the risk for thiamine deficiency.…”

Section: Prevalence Of Thiamine Deficiency and Burden Of Tddsmentioning

confidence: 99%

See 2 more Smart Citations

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Whitfield

Bourassa

Adamolekun

et al. 2018

Annals of the New York Academy of Sciences

241

335

View full text Add to dashboard Cite

Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.

show abstract

Thiamine deficiency in childhood with attention to genetic causes: Survival and outcome predictors

Ortigoza‐Escobar

Alfadhel

Molero-Luís

et al. 2017

Annals of Neurology

119

View full text Add to dashboard Cite

Primary and secondary conditions leading to thiamine deficiency have overlapping features in children, presenting with acute episodes of encephalopathy, bilateral symmetric brain lesions, and high excretion of organic acids that are specific of thiamine-dependent mitochondrial enzymes, mainly lactate, alpha-ketoglutarate, and branched chain keto-acids. Undiagnosed and untreated thiamine deficiencies are often fatal or lead to severe sequelae. Herein, we describe the clinical and genetic characterization of 79 patients with inherited thiamine defects causing encephalopathy in childhood, identifying outcome predictors in patients with pathogenic SLC19A3 variants, the most common genetic etiology. We propose diagnostic criteria that will aid clinicians to establish a faster and accurate diagnosis so that early vitamin supplementation is considered. Ann Neurol 2017;82:317-330.

show abstract

Infantile Wernicke's encephalopathy

Cited by 16 publications

References 3 publications

Infantile encephalitic beriberi: magnetic resonance imaging findings

Infantile encephalitic beriberi: magnetic resonance imaging findings

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Thiamine deficiency in childhood with attention to genetic causes: Survival and outcome predictors

Contact Info

Product

Resources

About