Infants Born to Mothers With a New Coronavirus (COVID-19)

Chen, Yan; Peng, Hua; Wang, Lin; Yin, Zhang; Zeng, Lingkong; Gao, Hui; Liu, Yalan

doi:10.3389/fped.2020.00104

Cited by 354 publications

(407 citation statements)

References 13 publications

Supporting

Mentioning

367

Contrasting

Unclassified

Order By: Relevance

“…In the cohort reported by Chen et al [36] three of the four infants tested negative for SARS-CoV-2 using a throat swab specimen and one couldn't be tested because of parental refusal: two of the four infants were healthy. Two of the four infants had rashes after birth, however, the rash distribution and shape differed (respectively, some maculopapules scattered all over the body and small military red papules on the forehead).…”

Section: Clinical Features In Newborns and Infantsmentioning

confidence: 96%

“…There is currently no evidence showing vertical transmission and intrauterine SARS-CoV-2 infection in foetuses of women developing COVID-19 pneumonia in late pregnancy. Table 1 summarizes clinical characteristics of the cases described in literature to date [33][34][35][36][37][38], although data are available only on a small sample size. We included also an unpublished case of a preterm infant born to a mother with COVID-19, in Bruxelles, Belgium.…”

Section: Maternal-foetal Transmission and Breastfeedingmentioning

confidence: 99%

See 1 more Smart Citation

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

et al. 2020

View full text Add to dashboard Cite

Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life.

show abstract

Section: Clinical Features In Newborns and Infantsmentioning

confidence: 96%

Section: Maternal-foetal Transmission and Breastfeedingmentioning

confidence: 99%

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Infants born vaginally or by caesarean section, to mothers with coronavirus infection, have so far been shown to be negative to COVID-19. This is based on: an observational study of 4 mothers infected with COVID-19 and 3 newborns [12]; a single case report [9]; and an observational study on 11 mothers infected with COVID-19 and their newborns [10].…”

Section: Clinical Findingsmentioning

confidence: 99%

COVID-19 and maternal mental health: Are we getting the balance right?

Topalidou

Thomson

Downe

2020

Preprint

View full text Add to dashboard Cite

This paper presents a rapid evidence review into the clinical and psychological impacts of COVID-19 on perinatal women and their infants. Literature search revealed that there is very little formal evidence on the impact of COVID-19 on pregnant, labouring and postnatal women or their babies. The clinical evidence to date suggests that pregnant and childbearing women, and their babies are not at increased risk of either getting infected, or of having severe symptoms or consequences than the population as a whole. There is no evidence on the short-and longer-term psychological impacts of restrictive practices or social and personal constraints for childbearing women during COVID-19 in particular, or infection pandemics in general. The potential for adverse mental health consequences of the pandemic should be recognised as a critical public health concern, together with appropriate care and support to prevent and ameliorate any negative impacts.

show abstract

“…At least five neonates born to pregnant women with COVID-19 pneumonia were reported to test positive for SARS-CoV-2 infection after birth [16][17][18] and other studies report newborns with elevated virus-specific antibodies to SARS-CoV-2 born to mothers with COVID-19 16,19 . However, several other studies have thus far failed to find evidence for intrauterine transmission from pregnant women with COVID-19 to their newborns in cohorts as large as 38 patients [20][21][22] . Additionally, newborns from 9 COVID-19 patients who had cesarean deliveries in their third trimester tested negative for SARS-CoV-2 17 .…”

Section: Introductionmentioning

confidence: 99%

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Muus

Luecken

Eraslan

et al. 2020

Preprint

251

326

View full text Add to dashboard Cite

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2 (ACE2) and associated proteases, transmembrane protease serine 2 (TMPRSS2) and Cathepsin L (CTSL), were previously identified as mediators of SARS-CoV2 cellular entry. Here, we assess the cell type-specific RNA expression of ACE2, TMPRSS2, and CTSL through an integrated analysis of 107 single-cell and single-nucleus RNA-Seq studies, including 22 lung and airways datasets (16 unpublished), and 85 datasets from other diverse organs. Joint expression of ACE2 and the accessory proteases identifies specific subsets of respiratory epithelial cells as putative targets of viral infection in the nasal passages, airways, and alveoli. Cells that co-express ACE2 and proteases are also identified in cells from other organs, some of which have been associated with COVID-19 transmission or pathology, including gut enterocytes, corneal epithelial cells, cardiomyocytes, heart pericytes, olfactory sustentacular cells, and renal epithelial cells. Performing the first meta-analyses of scRNA-seq studies, we analyzed 1,176,683 cells from 282 nasal, airway, and lung parenchyma samples from 164 donors spanning fetal, childhood, adult, and elderly age groups, associate increased levels of ACE2, TMPRSS2, and CTSL in specific cell types with increasing age, male gender, and smoking, all of which are epidemiologically linked to COVID-19 susceptibility and outcomes. Notably, there was a particularly low expression of ACE2 in the few young pediatric samples in the analysis. Further analysis reveals a gene expression program shared by ACE2 + TMPRSS2 + cells in nasal, lung and gut tissues, including genes that may mediate viral entry, subtend key immune functions, and mediate epithelial-macrophage cross-talk. Amongst these are IL6, its receptor and co-receptor, IL1R, TNF response pathways, and complement genes. Cell type specificity in the lung and airways and smoking effects were conserved in mice. Our analyses suggest that differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.

show abstract

Infants Born to Mothers With a New Coronavirus (COVID-19)

Cited by 354 publications

References 13 publications

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far

COVID-19 and maternal mental health: Are we getting the balance right?

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Contact Info

Product

Resources

About