Infants Born to Mothers With Severe Acute Respiratory Syndrome

Shek, Chi Chiu; Ng, Pak Cheung; Fung, Gabriel Pui Cheong; Cheng, Frankie Wai Tsoi; Chan, Paul K.S.; Peiris, Malik; Lee, Kim H.; Wong, Shiu F.; Cheung, Hon Ming; Li, Albert M.; Hon, Ellis K.L.; Yeung, Chung Kwong; Chow, Chun Bong; Tam, John S.; Chiu, Man Chun; Fok, Tai Fai

doi:10.1542/peds.112.4.e254

Cited by 218 publications

(223 citation statements)

References 9 publications

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“…None of the newborns was found to be dysmorphic at birth, and all of them followed a clinical course typical of infants with similar gestations. Our data suggest that these infants are not shedding the virus and have not been clinically infected [10].…”

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 59%

“…Our data suggest that the coronavirus is unlikely to be transferred via the intrauterine route, and none of the newborn infants was shedding the virus or developed SARS-CoV infection [10]. However, their abdominal signs and symptoms should be carefully monitored after delivery, and growth and neurodevelopment deserve long-term follow-up.…”

Section: Discussionmentioning

confidence: 83%

“…The amniotic fluid samples were also negative for SARS-CoV. The acute and convalescent serological titres of the infants did not show a 4-fold increase in antibody concentration to SARS-CoV [10]. None of the newborns was found to be dysmorphic at birth, and all of them followed a clinical course typical of infants with similar gestations.…”

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 91%

“…The only newborn survivor in the first trimester group was delivered at term and had a normal weight at birth. In addition, all newborns in the second and third trimester group survived [10]. Of the latter group of infants, 3 were delivered by emergency Caesarean section during the acute phase of illness, between 26 and 32 weeks' gestation, and the other 2 were delivered in the convalescent phase at 33 weeks' gestation and term, respectively.…”

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 99%

“…Second, the severe gastrointestinal complications in the most premature infants are also worrying. The 26 and 28 weeks' gestation infants developed jejunal perforation and necrotising enterocolitis, respectively [10]. Although such complications might have been coincidental, it could be related to the adverse perinatal events and/or the effects of prostaglandin modulating drugs, including high dose antenatal systemic corticosteroids and postnatal usage of indomethacin, disrupting the gastrointestinal mucosal integrity [11].…”

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 99%

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SARS in Newborns and Children

Leung

Chiu

et al. 2004

Neonatology

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The severe acute respiratory syndrome (SARS) is a highly contagious infection caused by a newly discovered strain of coronavirus (SARS-CoV). Infants born to pregnant women with SARS did not appear to acquire the infection through vertical transmission. Some newborn infants, however, developed severe intrauterine growth retardation and life-threatening gastrointestinal complications. It is now known that the clinical course and prognosis are different between paediatric and adult SARS patients. Young children (<12 years), in general, run a less aggressive clinical course than do teenage and adult patients. Thus far, no fatalities have been reported in the paediatric age group (≤18 years). This review describes the current understanding of the clinical manifestations, diagnostic tests, immunological profiles, patient management and outcomes of SARS-CoV infection in the paediatric population.

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Section: Newborns Born To Mothers With Sarsmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 83%

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 91%

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 99%

Section: Newborns Born To Mothers With Sarsmentioning

confidence: 99%

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SARS in Newborns and Children

Leung

Chiu

et al. 2004

Neonatology

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Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes

McClymont

Albert

Alton

et al. 2022

JAMA

131

129

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IMPORTANCEThere are limited high-quality, population-level data about the effect of SARS-CoV-2 infection on pregnancy using contemporaneous comparator cohorts.OBJECTIVES To describe maternal and perinatal outcomes associated with SARS-CoV-2 infection in pregnancy and to assess variables associated with severe disease in the pregnant population.DESIGN, SETTING, AND PARTICIPANTS CANCOVID-Preg is an observational surveillance program for SARS-CoV-2-affected pregnancies in Canada. This analysis presents exploratory, population-level data from 6 Canadian provinces for the period of March 1, 2020, to October 31, 2021. A total of 6012 pregnant persons with a positive SARS-CoV-2 polymerase chain reaction test result at any time in pregnancy (primarily due to symptomatic presentation) were included and compared with 2 contemporaneous groups including age-matched female individuals with SARS-CoV-2 and unaffected pregnant persons from the pandemic time period.EXPOSURE SARS-CoV-2 infection during pregnancy. Incident infections in pregnancy were reported to CANCOVID-Preg by participating provinces/territories. MAIN OUTCOMES AND MEASURESMaternal and perinatal outcomes associated with SARS-CoV-2 infection as well as risk factors for severe disease (ie, disease requiring hospitalization, admission to an intensive care unit/critical care unit, and/or oxygen therapy). RESULTS Among 6012 pregnant individuals with SARS-CoV-2 in Canada (median age, 31 [IQR, 28-35] years), the greatest proportion of cases were diagnosed at 28 to 37 weeks' gestation (35.7%). Non-White individuals were disproportionately represented. Being pregnant was associated with a significantly increased risk of SARS-CoV-2-related hospitalization compared with SARS-CoV-2 cases among all women aged 20 to 49 years in the general population of Canada (7.75% vs 2.93%; relative risk, 2.65 [95% CI, 2.41-2.88]) as well as an increased risk of intensive care unit/critical care unit admission (2.01% vs 0.37%; relative risk, 5.46 [95% CI, 4.50-6.53]). Increasing age, preexisting hypertension, and greater gestational age at diagnosis were significantly associated with worse maternal outcomes. The risk of preterm birth was significantly elevated among SARS-CoV-2-affected pregnancies (11.05% vs 6.76%; relative risk, 1.63 [95% CI, 1.52-1.76]), even in cases of milder disease not requiring hospitalization, compared with unaffected pregnancies during the same time period. CONCLUSIONS AND RELEVANCEIn this exploratory surveillance study conducted in Canada from March 2020 to October 2021, SARS-CoV-2 infection during pregnancy was significantly associated with increased risk of adverse maternal outcomes and preterm birth.

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SARS in Children

Leung¹

2005

Severe Acute Respiratory Syndrome

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Infants Born to Mothers With Severe Acute Respiratory Syndrome

Cited by 218 publications

References 9 publications

SARS in Newborns and Children

SARS in Newborns and Children

Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes

SARS in Children

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