Infarct-Necrosis of the Liver in a Patient with S-A Hemoglobin

Mengel, Charles E.; Schauble, James F.; Hammond, Charles B.

doi:10.1001/archinte.1963.03620250097013

Cited by 16 publications

(4 citation statements)

References 14 publications

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“…A review of the English language literature revealed additional 26 cases of hepatic infarction during pregnancies in 24 women [7–26]. The description herein includes both these 24 women and our four patients, a total of 30 pregnancies in 28 women.…”

Section: Resultsmentioning

confidence: 98%

“…One patient was homozygous for the factor (F) V Leiden mutation [24] and one was heterozygous for FII polymorphism G20210A (our case 1). Two patients had sickle cell trait [9,13].…”

Section: Resultsmentioning

confidence: 99%

“…Arterial thrombosis of both the large and small hepatic arteries are also seen [34–36]. The pathological findings in the patients reviewed, showed areas of necrosis, small vessels occlusive disease and inflammatory changes [8–12,14,17,26].…”

Section: Discussionmentioning

confidence: 99%

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Hepatic infarctions during pregnancy are associated with the antiphospholipid syndrome and in addition with complete or incomplete HELLP syndrome

Pauzner¹,

Dulitzky²,

Carp³

et al. 2003

Journal of Thrombosis and Haemostasis

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Summary. Antiphospholipid antibody syndrome (APS) is associated with adverse pregnancy outcomes and maternal complications including thrombotic events and early pre‐eclampsia. HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets) represents a unique form in the spectrum of pre‐eclampsia. This report describes four patients with pregnancy‐associated hepatic infarctions. All four had APS and HELLP syndrome, which was complete in one patient and incomplete in three patients, with elevated liver enzymes in all, and either thrombocytopenia or hemolysis in two. In the literature, we found descriptions of an additional 24 patients who had 26 pregnancies with concomitant hepatic infarction. Of the total 28 patients, anticardiolipin antibodies (aCL) and/or lupus anticoagulant (LAC) were assessed in 16 patients, out of whom 15 were found to be positive. Hepatic infartction during pregnancy was associated almost always with APS, with HELLP (2/3 complete, 1/3 incomplete), and only in one‐third of the pregnancies with pre‐eclampsia (PE).

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Section: Resultsmentioning

confidence: 98%

“…One patient was homozygous for the factor (F) V Leiden mutation [24] and one was heterozygous for FII polymorphism G20210A (our case 1). Two patients had sickle cell trait [9,13].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hepatic infarctions during pregnancy are associated with the antiphospholipid syndrome and in addition with complete or incomplete HELLP syndrome

Pauzner¹,

Dulitzky²,

Carp³

et al. 2003

Journal of Thrombosis and Haemostasis

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“…Liver infarction has been reported in 34% of autopsies [7]. The SCA associated blood viscosity predisposes to infarction [8,9]. The liver enzymes activity increased abnormally [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Antisickling Effect of the Arthrospira platensis bilins for Liver Protection: a Modeling, Hypothesis, and Food for Thought

Amara¹

2017

SOJB

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The increase in the number of the liver injury and diabetic patients' worldwide and particularly in sub-Sahara in Africa put a signal about that it might be a link between it and the regional diseases such as Malaria and Sickle Cell Anemia (SCA). SCA is a genetic based disease and is one of the liver injury causative agents. Chronic liver injury patients' are susceptible to more complications such as the infection with viruses (e.g. Virus C), diabetic, immune disease, weakness, anemia etc. Arthrospira platensis proves be able to fight and to protect against different diseases at once. It has antiviral, antioxidant, antisickling, nutrient, and edible. In this study their bilins are evaluated for their antisickling effect using molecular modeling aiming to protect patients with SCA particularly the diabetic ones. In this study molecular modeling for the normal and sickle β-globin, molecules against five bilins [(1) Red bilin, (2) 21H-Bilin-1(22H)-one, (3) 21H-Bilin-1(24H)-one, (4) 1H-Bilin 1 one, and (5) 22H-Biline (21-bilin)] were investigated using protein modeling and docking. MODELLER v 9.8, Hex ver 8.0.0 and Discovery Studio 4.1 Client 4.1.0.14169 (Accelrys software Inc.) were used for modeling and docking. A. platensis bilins are evaluated also by comparing the visualized docking results. The total energy of the system (the molecule) for all of the used bilins with the sickle β-globin molecule particularly in both of the presence or the absence of the porphyrin ring prove to improve such energy to be almost equal to that obtained from the normal β-globin (with or without porphyrin ring). However, porphyrin ring is essential. A. platensis bilins using molecular modeling prove to be able to stabilize the sickle β-globin molecules particularly in the presence of the porphyrin ring. As being multifunction, it is recommended either as native biomass or as purified bilins to be used for the treatment of the SCA and the protection against further liver deterioration.

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