Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

Skenderi, Faruk; Krakonja, Fikreta; Vranić, Semir

doi:10.1186/1746-1596-8-38

Cited by 23 publications

(17 citation statements)

References 26 publications

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“…9 Skenderi et al, reported case of spontaneous infarction in fibroadenoma not associated with pregnancy or lactation or fine needle aspiration. 10 In this case also the infarction was not related with pregnancy, lactation or FNAC. In this case the diagnosis of fibroadenoma with infarction was suggested on cytology.…”

Section: Discussionsupporting

confidence: 48%

Clinical and histopathological correlation of breast lesions

2018

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Background: To study the histopathological features of neoplastic and non neoplastic lesions of breast. To correlate the pathological findings with clinical parameters.Methods: We have studied total 170 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification.Results: Out of the 170 cases, 128 cases had neoplastic lesions and 41 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 51 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 62 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were mucinous carcinoma (2 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 6 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4th decade. The nonneoplastic lesions were common in 4th decade.Conclusions: Histopathological study is important in the management of breast lesions.

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Section: Discussionsupporting

confidence: 48%

Clinical and histopathological correlation of breast lesions

2018

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“…Spontaneous infarction can be seen in focal breast lesions such as fibroadenoma, phyllodes tumors, intraductal papilloma, and lactating adenoma . Spontaneous infarction of fibroadenomas can be associated with pregnancy, lactation, or recent FNA or core biopsy or without any inciting event .…”

Section: Discussionmentioning

confidence: 99%

Breast Necrosis after Chemotherapy for Recurrent Ovarian Cancer: Report of a Case and Review of the Literature

et al. 2015

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“…The cytological characteristic features of PC of the breast seem to reflect the histopathological ones, exhibiting numerous individual bizarre and giant malignant cells with pleomorphic irregular nuclei, coarse chromatin, conspicuous nucleoli, very high mitotic rate, and relatively abundant cytoplasm in the background of possible inflammation and/or necrosis [6-8]. Indeed, when extensive necrosis is present without evidence of viable PC cells on cytology specimens, cytopathologists should exclude out the possibility of benign breast tumors, e.g., infarcted fibroadenoma [13]. On the other hand, we for the first time indicate that cohesive, three-dimensional and/or sheet-like clusters of highly malignant cells coexist on PC cytology.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC

et al. 2013

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A mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nucleated, and/or giant cells having hyperchromatic pleomorphic nuclei, prominent nucleoli, and relatively abundant cytoplasm, admixed with numerous mitotic figures in a hemorrhagic or inflammatory background. A small amount of sheet-like or three-dimensional clusters of malignant cells coexisted. We first interpreted it as high-grade malignancy, such as invasive carcinoma, not otherwise specified. A right breast-conserving surgery was performed, and gross examination revealed a cystic cavity-formed and solid tumor lesion, measuring 35 × 35 × 25 mm and looking gray-yellowish to -whitish. On microscopic examination, the tumor was composed of a diffuse proliferation of highly atypical cells devoid of adhesive characteristics, including many multi-nucleated giant bizarre cells, in a haphazard fashion with stromal invasion, alternating with sarcomatoid features of spindle tumor cells. The cystic cavity was surrounded by hemorrhagic and inflammatory granulation tissue and lined by mostly denuded but atypical tumor cells or bland-looking flattened epithelial cells. Immunohistochemically, these tumor cells are specifically positive for all epithelial markers. Therefore, we made a conclusive diagnosis of pleomorphic carcinoma of the breast with cyst formation. We should be aware that, owing to its characteristic findings, cytopathologists can diagnose correctly, based on careful cytological examination of adequate samplings.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9290689448998782

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Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

Cited by 23 publications

References 26 publications

Clinical and histopathological correlation of breast lesions

Clinical and histopathological correlation of breast lesions

Breast Necrosis after Chemotherapy for Recurrent Ovarian Cancer: Report of a Case and Review of the Literature

Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC

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