Infección por Trypanosoma cruzi en mujeres puérperas y sus neonatos en Barcelona, estado Anzoátegui, Venezuela

Zabala, Norielis; Berrizbeitia, Mariolga; Jorquera, Alicia; Rodríguez, Jessicca; Romero, Leomery

doi:10.7705/biomedica.4606

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…The likelihood of acquiring a T. cruzi infection can vary significantly. In a study with puerperal women and their newborns in Venezuela, a 2.5-fold increase in the likelihood of acquiring a T. cruzi infection was observed among those residing in rural areas compared to those in urban areas [71]. This finding differs from research in Argentina, where the prevalence of CD in urban indigenous communities was 6.4 times higher than in rural communities [55].…”

Section: ➢ Residence Locationmentioning

confidence: 65%

“…The two articles that presented the OR value found an increase from 1.75 to 4.8 times in the odds of finding an individual with CD due to humans with CD. The fact of patients having coexisted with host family members at any given time, without cohabitation, finding an increase of 1.7 in the odds of seropositivity due to the aforementioned variable [71].…”

Section: ➢ Humans With Chagas Diseasementioning

confidence: 99%

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Predictor Variables in the Spread of Chagas Disease in Rural Areas

de Sousa Leite,

de Rezende Feres,

Scalize

2024

Pathogens

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Over a hundred years ago after the discovery of Chagas disease (CD) in Brazil, the World Health Organization estimates a number of 6 to 7 million people infected by Trypanosoma cruzi worldwide. Therefore, the goal of this work was to identify variables related to the spread of infection by T. cruzi in humans living in rural areas, seeking predictor variables. A systematic review of the literature has been conducted, with a search in the Scopus platform, using the search string “Chagas disease” and “rural”, resulting in 85 valid and analyzed scientific studies (1977 and 2022). Twenty-seven predictor variables have been acquired, and 19 of them have been grouped, such as: socioeconomic and educational, housing, environmental, sanitary, and cultural; and 8 variables related to T. cruzi seropositive individuals. The predictor variables yielded significant results (p-value < 0.05) in 59.5% of the cases (195/328), with a median of 66.7%. In other words, studies relating to 50% of the 27 variables showed significance equal to or greater than 66.7% of the time. The independent variables with the highest proportion of significant data (p-value < 0.05) were Education (87.6%), Intradomicile building (70%), Domestic animals (69.6%), and Triatomines (69.2%) in the households. Some variables reached 100%; however, few articles were found, indicating the need for further research, especially for Sanitation and Culture. It has been concluded that, in the several contexts found, the social vulnerability and lack of information led the individual to living in environments where inhabitability is inadequate, to perform limited work activity and develop habits and behaviors which impair them in an environmental insalubrity situation, favorable to the access of vectors and pathogens of anthropozoonoses such as CD.

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Section: ➢ Residence Locationmentioning

confidence: 65%

Section: ➢ Humans With Chagas Diseasementioning

confidence: 99%

Predictor Variables in the Spread of Chagas Disease in Rural Areas

de Sousa Leite,

de Rezende Feres,

Scalize

2024

Pathogens

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“…In the case of ChD, the real magnitude or dimension of the problem in Venezuela is unknown since there is no official information on cases or prevalence in endemic areas, but, based on the data published by researchers from autonomous universities [46,47] and the growing number of reports of ChD acquired by the oral route [48][49][50][51][52][53][54][55], we estimate that the universe of infected T. cruzi population has increased.…”

Section: Final Remarksmentioning

confidence: 99%

Ten years follow-up of the largest oral Chagas disease outbreak: Cardiological prospective cohort study

Ruiz-Guevara,

Alarcón de Noya,

Mendoza

et al. 2023

PLoS Negl Trop Dis

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Background Chagas disease (ChD) is the most important endemy in Latin America. Some patients, develop chronic Chagasic cardiopathy (CCC) years after the acute phase. It is unknown if patients infected by the oral route have higher risk of developing early CCC. Methods and findings A prospective cohort study was conducted to assess morbidity and mortality during 10 years observation in 106 people simultaneously infected and treated in the largest known orally transmitted ChD outbreak in 2007. A preschooler died during the acute phase, but thereafter was no mortality associated to ChD. All acute phase findings improved in the first-year post-treatment. Each person was evaluated 8.7 times clinically, 6.4 by electrocardiogram (ECG)/Holter, and 1.7 by echocardiogram. Based on prevalence, the number of people who had any abnormalities (excluding repolarization abnormalities and atrial tachycardia which decreased) was higher than 2007, since they were found at least once between 2008–2017. However, when we evaluated incidence, except for clinical bradycardia and dizziness, it was observed that the number of new cases of all clinical and ECG findings decreased at the end of the follow-up. Between 2008–2017 there was not incidence of low voltage complex, 2nd degree AV block, long QT interval, left bundle branch block or left ventricular dysfunction that allowed the diagnosis of CCC. Total improvement prevailed over the persistence of all clinical and ECG/Holter findings, except for sinus bradycardia. Incomplete right bundle branch block, sinus bradycardia and/or T-wave inversion were diagnosed persistently in 9 children. The second treatment did not have significant influence on the incidence of clinical or ECG/Holter findings. Conclusions At the end of the 10-year follow-up, there were not clinical or ECG/Holter criteria for classifying patients with CCC. The incidence of arrhythmias and repolarization abnormalities decreased. However, special attention should be paid on findings that not revert as sinus bradycardia, or those diagnosed persistently in all ECG as sinus bradycardia, incomplete right bundle branch block or T-wave inversion. Early diagnosis and treatment may have contributed to the rapid improvement of these patients. In ChD follow-up studies prevalence overestimates the real dimension of abnormalities, the incidence looks as a better indicator.

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Infecção Alimentar (Via Oral) Por Trypanosoma Cruzi E Seus Impactos Na Saúde Pública: Uma Revisão

Oliveira¹,

Bezerra²

2020

RIS

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OBJETIVO: Realizar revisão de literatura com intuito de identificar a incidência da transmissão via oral da Doença de Chagas por meio de alimentos contaminados e seus impactos no âmbito da saúde publica. MÉTODO: Trata-se de uma revisão de literatura, que utilizou busca de acesso online às bases como Science Direct, Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Lilacs, Scielo, Medline, PubMed, Biblioteca Virtual em Saúde com os descritores “T. cruzi” “Epidemiologia” e/ou “Saúde Pública”. RESULTADO: E possivel identificar que o numero de casos da doenca de chagas humana teve um crescimento significativo quando associado a transmissão por via oral, apresentado um cenario de risco quando analisado em alimentos como com a polpa do açai e caldo da cana de açucar. CONCLUSÃO: Com isso considera-se que se faz necessario a aplicabilidade de politicas publicas de saúde que possam contribuir para as ações de prevenção, promoção da saúde e controle da doença, alem da necessidade de disseminar o conhecimento das mais diversas formas de transmissão da doença e os seus riscos, tornando assim em evidencia a necessidade de uma abordagem multiprofissional, permitindo que a tematica permei por outras areas de atuação profissional de forma continua. Palavras chave: Doença de Chagas; Triatomíneo; Vetor.

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Infección por Trypanosoma cruzi en mujeres puérperas y sus neonatos en Barcelona, estado Anzoátegui, Venezuela

Cited by 3 publications

References 30 publications

Predictor Variables in the Spread of Chagas Disease in Rural Areas

Predictor Variables in the Spread of Chagas Disease in Rural Areas

Ten years follow-up of the largest oral Chagas disease outbreak: Cardiological prospective cohort study

Infecção Alimentar (Via Oral) Por Trypanosoma Cruzi E Seus Impactos Na Saúde Pública: Uma Revisão

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