Infección por virus linfotrópico de células T humanas tipo 1 en pacientes con diagnóstico de tuberculosis multidrogorresistente

Cachay, Rodrigo; Schwalb, Alvaro; Mora, Romina; Cáceres, Tatiana; Gotuzzo, Eduardo

doi:10.17843/rpmesp.2019.361.4232

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…In this study, it was observed that 33.33% of the individuals assessed presented HTLV/tuberculosis co-infection, as immunological alterations induced by HTLV-1 may precede a high susceptibility to tuberculosis (TB) co-infection [19]. The literature shows a higher prevalence of this co-infection, especially in countries endemic to both infections such as Brazil and Peru [20].…”

Section: Discussionmentioning

confidence: 92%

Benefits of inspiratory muscle training under indirect home supervision in patients with human T-cell lymphotropic virus type 1

et al. 2020

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Introduction: The presence of human T-cell lymphotropic virus type 1 (HTLV-1) associated with neuropathy (myelopathy/tropical spastic paraparesis - HAM/TSP), can generate morphological and functional changes in the respiratory system. As a preventive therapeutic possibility for respiratory dysfunctions, it is expected that the already conceptualized inspiratory muscle training, when performed at home, can be a therapeutic resource that favors adherence to treatment. Objective: To evaluate respiratory muscle strength in patients with HTLV-1 after participating in a home respiratory muscle training protocol under indirect supervision. Method: This was a clinical, longitudinal, prospective, quantitative, and single-center trial approved by the Research Ethics Committee of the State University of Pará, opinion no. 2.695.505 and registered in clinical trials NCT03829709. Six HTLV-1 patients participated in a 5-week home respiratory muscle training protocol lasting 30 minutes daily through a linear load inspiratory muscle trainer. For the characterization of the imposed load, they were submitted to manovacuometry during pre (T0), peri (T3), and post (T5) treatment. Results: Six individuals completed the program, of which 83.33% were female and 16.66% male. With the application of respiratory muscle training, it was possible to achieve a significant increase (p < 0.011) of the maximum inspiratory pressure as shown when comparing T0 (66.8±12.58) to T5 (115.08±31.78). Conclusion: This study identified an increase in inspiratory muscle strength after HTLV-1 patients participated in a home muscle training protocol under indirect supervision.

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Section: Discussionmentioning

confidence: 92%

Benefits of inspiratory muscle training under indirect home supervision in patients with human T-cell lymphotropic virus type 1

et al. 2020

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“…Additionally, the prevalence of HTLV-1 has been estimated between 1–2% of the Peruvian population [ 19 ]. The co-infection of HTLV-1 with TB has been estimated between 2.8% to 5.6% among drug-susceptible and multidrug-resistant TB, respectively [ 13 , 20 ]. Few studies have characterized the lung lesions of HTLV-1 infected patients amongst those without known TB history.…”

Section: Introductionmentioning

confidence: 99%

Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

et al. 2021

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The lifelong infection with the human T lymphotropic virus type 1 (HTLV-1) has been associated with a variety of clinical manifestations; one of the less-explored is HTLV-1-associated pulmonary disease. Imaging of lung damage caused by the HTLV-1 hyperinflammatory cascade can be similar to sequelae from TB infection. Our study aims to describe the pulmonary lesions of HTLV-1-positive patients without past or current active TB and evaluate pulmonary function. We found that nine out of fourteen patients with no known TB disease history presented bronchiectasis, mainly found bilaterally while five presented pulmonary fibrosis. A normal pattern was found in most patients with a pulmonary functional test. Furthermore, there was no association between the PVL and the chest-CT scan findings, nor with spirometry results. However, the sample size was insufficient to conclude it.

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Infección por virus linfotrópico de células T humanas tipo 1 en pacientes con diagnóstico de tuberculosis multidrogorresistente

Cited by 2 publications

References 3 publications

Benefits of inspiratory muscle training under indirect home supervision in patients with human T-cell lymphotropic virus type 1

Benefits of inspiratory muscle training under indirect home supervision in patients with human T-cell lymphotropic virus type 1

Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

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