Infeccion Respiratoria Por Adenovirus en Pediatria: De Ayer a Hoy

C, Luis F Avendaño

doi:10.51451/np.v14i1.86

Cited by 3 publications

(22 citation statements)

References 16 publications

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“…HAdVs are members of the family Adenoviridae and Genus Mastadenovirus. There are currently more than 85 types of HAdV reported (33,34,35) but the pathogenicity of many of them is unknown (9,34). HAdVs are classified into seven species (A-G), with multiple types in each of them (36).…”

Section: Hadv Classification (Types)mentioning

confidence: 99%

“…HAdV, linear double-stranded DNA, 25-48 kbp in length, are very stable in the environment, do not have a lipid envelope, and are less vulnerable to lipid-soluble detergents (9,24). HAdV can remain for weeks in the environment and when frozen at -20ºC it survives for years, which generates a comparative advantage over other viruses to remain stable on surfaces, which is also advantageous for researchers to carry out studies with samples frozen for years (9,37).…”

Section: Virological Characteristics Of Hadv and Its Pathogenesismentioning

confidence: 99%

“…Unlike the respiratory syncytial virus and influenza viruses, which have a clear seasonal predominance, respiratory HAdV generates outbreaks continuously throughout the year, as the SARS-CoV-2 pandemic has behaved up to now (1,9,10).…”

Section: Introductionmentioning

confidence: 99%

“…The infection is usually self-limiting, but persistent viral excretion has been described for 4 weeks, even up to 18 months in the preschool population and immunosuppressed patients (14,15). In some studies, they have postulated that this mechanism would be the source of endemic circulation and sometimes of epidemic outbreaks in certain closed populations (9,16). A high prevalence of HAdV has been described in some populations, particularly type 5, one of the most studied in humans.…”

Section: Introductionmentioning

confidence: 99%

“…Transmission of HAdV in swimming pools by fecal-oral mechanism has been documented in the literature, in waters contaminated with stools from patients carrying HAdV, mainly in non-chlorinated swimming pools (23). It has been shown that HAdV can be transmitted between people with poor hand hygiene since this virus can replicate in epithelial cells of the gastrointestinal and respiratory tracts, ocular conjunctiva, and even in the bladder (9,24).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An Old Acquaintance. Could Adenovirus be our Next Pandemic Threat?

Saint-Pierre¹,

Conei²,

Lizama³

et al. 2022

Preprint

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Human adenoviruses are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 85 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25-48 kbp, 90 nm in diameter, without a mantle, stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. The objective of this review is to recognize the variability of HAdV, the pandemic potential that a recombinant could present between HAdV-3 and 7 viral types, known to produce aggressive outbreaks in health facilities. The review determined the characteristics of HAdV, from the infection to treatment, vaccine development and the evaluation of the social determinants of health associated with HAdV, guiding the necessary measures for future sanitary control, and preventing disasters such as the SARS-CoV-2 pandemic.

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Section: Hadv Classification (Types)mentioning

confidence: 99%

Section: Virological Characteristics Of Hadv and Its Pathogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Old Acquaintance. Could Adenovirus be our Next Pandemic Threat?

Saint-Pierre¹,

Conei²,

Lizama³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

Saint-Pierre

Conei

Lizama

et al. 2023

Viruses

View full text Add to dashboard Cite

Human adenoviruses (HAdV) are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 110 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25–48 kbp, 90 nm in diameter, without a mantle, are stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. This review aimed to highlight the HAdV variability and the pandemic potential that a HAdV3 and 7 recombinant could have considering the aggressive outbreaks produced in health facilities. Herein, we described the characteristics of HAdV, from the infection to treatment, vaccine development, and the evaluation of the social determinants of health associated with HAdV, suggesting the necessary measures for future sanitary control to prevent disasters such as the SARS-CoV-2 pandemic, with an emphasis on the use of recombinant AdV vaccines to control other potential pandemics.

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