Infecciones nosocomiales por Candida y trombocitopenia en recién nacidos de muy bajo peso

Claveras, S Torres; Arenaz, M. Duplá; Delgado, Raquel Pérez; Mazas, Yolanda Aliaga; Moisés, Víctor Rebage

doi:10.1157/13113014

Cited by 2 publications

(3 citation statements)

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“…The rate of fungal isolates (12.6%) in the present study is similar to a previous report (3). Another study reported higher (19%) fungal isolates (7).…”

Section: Discussionsupporting

confidence: 91%

“…Charoo et al reported that 66% of fungal sepsis had thrombocytopenia (5). Torres et al found thrombocytopenia in 100% of Candida sepsis (7) and concluded that thrombocytopenia is a highly specific marker of fungal sepsis. We observed lower rates of thrombocytopenia in sepsis due to Candida spp.…”

Section: Discussionmentioning

confidence: 99%

“…In another study (5), rates of thrombocytopenia in coagulase negative Staphylococcus sepsis, Klebsiella sepsis and isolated fungal sepsis were 33.3%, 60%, and 66%, respectively. A spanish study reported thrombocytopenia in 100% of Candida sepsis (7). An Indian study (5) reported thrombocytopenia in 59.5% of nosocomial sepsis with mild, moderate, and severe thrombocytopenia in 27%, 20%, and 12.5%, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Severity of Thrombocytopenia in Blood Culture Proven Neonatal Sepsis: A Prospective Study

Bhat

Kousika

Lewis

et al. 2018

Arch Pediatr Infect Dis

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Background: The reported prevalence and pattern of thrombocytopenia in neonatal sepsis vary widely. Objectives: We aimed to determine the prevalence and severity of thrombocytopenia in blood culture proven neonatal sepsis. Methods: The study was conducted in a University hospital by recruiting neonates with sepsis in whom blood culture had grown microorganisms. The initial platelet count refers to the one obtained at the same time as the positive blood culture. Platelet counts were monitored 12-24 hourly. Thrombocytopenia was considered mild if between 50,000/mm 3 and 150,000/mm 3 , moderate if between 20,000/mm 3 and 50,000/mm 3 , and severe if < 20,000/mm 3 or < 50,000/mm 3 with clinical bleeding. Results: A total of 143 episodes of blood culture proven sepsis in 131 neonates were studied. Gram positive bacteria identified in 33.6%, gram negative bacteria in 53.8%, and fungi in 12.6%. Klebsiella predominated among Gram negative bacteria (39%) and Candida species (94.4%) among fungi. Initial thrombocytopenia was observed in 84 (58.7%) episodes; it was mild, moderate, and severe in 39.3%, 25%, and 35.7% respectively. Initial thrombocytopenia among Gram positive, Gram negative, and fungal sepsis were 41.7%, 70.1%, and 55.6%, respectively. Severe thrombocytopenia in the respective groups was 20%, 44.4% and 20%. Overall (80%) and severe thrombocytopenia (45.8%) was highest in Klebsiella sepsis. Thrombocytopenia was moderate in 60% of Candida sepsis. An additional 23.7% had thrombocytopenia subsequently. In 51.2%, thrombocytopenia persisted beyond 3 days. Conclusions: Thrombocytopenia was observed in 58.7% of culture proven neonatal sepsis. Initial thrombocytopenia was common among Gram negative sepsis and mostly of a moderate degree in Candida sepsis.

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“…The rate of fungal isolates (12.6%) in the present study is similar to a previous report (3). Another study reported higher (19%) fungal isolates (7).…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Severity of Thrombocytopenia in Blood Culture Proven Neonatal Sepsis: A Prospective Study

Bhat

Kousika

Lewis

et al. 2018

Arch Pediatr Infect Dis

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Candidemia en Recién Nacidos en El Hospital Universitario De Caracas

Rondón,

Ferrara,

Duarte

et al. 2020

ACTA CIENTIFICA SVBE

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La incidencia de candidemia en las unidades de cuidados intensivos neonatales ha aumentado considerablemente en la última década, debido al aumento en la supervivencia de los recién nacidos de bajo peso y a los cambios en los procedimientos diagnósticos y terapéuticos. Se diseñó un estudio descriptivo, retrospectivo de corte transversal, cuyo objetivo fue determinar la frecuencia de candidemia en la unidad de cuidados intensivos neonatales (UCIN) y la unidad de Cirugía Neonatal (UCNN) del Hospital Universitario de Caracas (HUC), en el período 2009-2012. Se realizó una revisión de los registros del laboratorio de micología del HUC, donde se escogieron los casos de recién nacidos hospitalizados en la UCIN y en la UCNN con resultado positivo para Candida spp. en al menos un hemocultivo entre el período de julio de 2009 y agosto 2012. Se incluyeron un total de 34 pacientes cuya media en edad gestacional fue de 33 semanas y 1735 g de peso al nacer. 15/34 requirieron cirugía, 32/34 neonatos recibieron nutrición parenteral, lo que representa 94.1%, así como también el 79.4 % necesitaron ventilación mecánica. 23/34 (67.6%) de los neonatos con candidemia recibieron antibióticos de amplio espectro por más de 21 días y la media de hospitalización fue de 43 días. La prevalencia en la UCIN fue de 1.2 %. La especie de Candida más aislada fue el complejo C. parapsilosis con un 85.1%. Todas las cepas fueron sensibles a caspofungina y anfotericina B; mientras que para fluconazol y voriconazol hubo un porcentaje de resistencia de 6.9% y 2.9% respectivamente. Se concluye que en la UCIN y en la UCNN del HUC el complejo C. parapsilosis es la más frecuente, existiendo factores de riesgos que favorecen su aparición.

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Infecciones nosocomiales por Candida y trombocitopenia en recién nacidos de muy bajo peso

Cited by 2 publications

References 0 publications

Prevalence and Severity of Thrombocytopenia in Blood Culture Proven Neonatal Sepsis: A Prospective Study

Prevalence and Severity of Thrombocytopenia in Blood Culture Proven Neonatal Sepsis: A Prospective Study

Candidemia en Recién Nacidos en El Hospital Universitario De Caracas

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