Infected and malignant fields are an absolute contraindication to intraoperative cell salvage: fact or fiction?

Mj, Thomas

doi:10.1046/j.1365-3148.1999.00207.x

Cited by 38 publications

(23 citation statements)

References 61 publications

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“…These factors can be measured in recipient's plasma. Dalén showed that approximately 0.5% of the recovered erythrocytes in drain-blood are haemolysed (Dalén & Enström 1998, 1999. The haematocrit level is lower in drain-blood due to dilution with chyle.…”

Section: Quality Of the Recovered Bloodmentioning

confidence: 99%

“…The haematocrit level is lower in drain-blood due to dilution with chyle. Filtration of drain blood through a leukocyte-reducing filter previous to www.intechopen.com collection in the container, and avoiding filtration after collection, may reduce erythrocyte damage (Dalén & Enström 1998, 1999.…”

Section: Quality Of the Recovered Bloodmentioning

confidence: 99%

“…The tumour cells remain viable and proliferate, as shown in in-vitro and animal models. Furthermore, leukocyte filtration can achieve just less than one more log reduction (Hanssen et al 2004(2x), 2006, Thomas MJG 1999. Radiation of the aspirated blood with 50 Gy resulted in a 10 log reduction in tumour load, after which no DNA-metabolism could be found (Thomas MJG 1999, Hanssen et al 2002.…”

Section: Tumour Surgerymentioning

confidence: 99%

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Autotransfusion: Therapeutic Principles, Efficacy and Risks

Gemert¹

2012

Blood Transfusion in Clinical Practice

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Section: Quality Of the Recovered Bloodmentioning

confidence: 99%

Section: Quality Of the Recovered Bloodmentioning

confidence: 99%

Section: Tumour Surgerymentioning

confidence: 99%

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Autotransfusion: Therapeutic Principles, Efficacy and Risks

Gemert¹

2012

Blood Transfusion in Clinical Practice

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“…They therefore should not be mistaken for circulating tumor cells or cells from peritoneal carcinosis that can be transfused without increasing the rate of metastasis [13]. They might not directly originate from a primary tumor or a filia that has turned to pure proliferation, regulated by circulatory access and immune surveillance, but might represent cells from the invasive frontline, where further progression of the malignant disease is decided.…”

Section: Tumor Cells In Wound Blood As a Form Of Disseminated Tumor Cmentioning

confidence: 99%

Advantages of Intraoperative Blood Salvage with Blood Irradiation in Cancer Surgery

Hansen¹,

Pawlik²,

Altmeppen³

et al. 2004

Transfus Med Hemother

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The demand for intraoperative blood salvage (IBS) in cancer surgery originates from the high transfusion rate, the unfavorable effects of anemia, and the special impact of transfusion risks such as immunomodulation in tumor patients. The advantages of IBS are availability, low waste rate, and excellent quality of the autologous, unstored blood. Effective elimination of tumor cell dissemination by retransfusion of wound blood can be achieved only by blood irradiation. Combining established methods of IBS and blood irradiation is feasible and allows efficient saving of blood. For Jehovah’s witnesses it may open the option of tumor surgery. From an anesthesiological point of view IBS blood is not a drug but part of the therapy. Even if it is viewed as drug, practical medicolegal regulations are in sight. IBS with blood irradiation provides the safest and best blood for optimal hemotherapy in tumor patients. In addition, first data indicate a better outcome of patients in whom IBS was performed.

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“…In patients with malignant ascites, tumor cells can be reinfused into the internal jugular vein via a peritoneo-jugular shunt, but despite a huge influx of malignant cells, pulmonary metastases are rare. 6 If tumor cells are still a concern, the blood may be irradiated or filtered to remove them effectively, 7,8 but in practical terms this may delay reinfusion for minutes or even hours.…”

Section: Contaminantsmentioning

confidence: 99%