Infected wound repair with an ultrasound-enhanced nanozyme hydrogel scaffold

Abstract

Chronic diabetic wounds persistently face the threat of evolving into diabetic foot ulcers owing to severe hypoxia, high levels of reactive oxygen species (ROS), and a complex inflammatory microenvironment. To...

Multifunctional antibacterial hydrogels for chronic wound management

“…169 Zhang et al designed a nanoenzyme-hydrogel scaffold (PNAs). 170 Under ultrasound, the surface plasmon resonance effect enhanced electron polarisation, effectively catalysing hydrogen peroxide, promoting glutathione synthesis, and enhancing the ROS scavenging ability. PNAs promote in vitro cell proliferation, migration, and angiogenesis, promote diabetic wound healing in vivo, and control the release of antibacterial components according to changes in specific active substances in infected wounds.…”

Gases and gas-releasing materials for the treatment of chronic diabetic wounds

“…Zhang et al designed a dynamic covalent bond hybrid of a metal–organic coordination polymer as a synthesis template (PNAs) to obtain a high-density platinum nanoparticle assembly. 89 The tight assembly of this compact platinum nanoparticle effectively mimics the antioxidant enzymes (CAT, POD). Through a series of enzymatic kinetics and in vitro studies, the authors confirmed that PNAs can simulate CAT and POD and catalyze hydrogen peroxide to produce O 2 and water (Fig.…”

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

“…An alternative strategy to combat hypoxia and boost cell survival involves incorporating catalase into the hydrogel system, although this approach is limited to ROS-accumulated areas, as oxygen generation relies on the catalase-mediated H 2 O 2 decomposition. 194 , 195 …”