Infection à Covid-19 en gériatrie au Sénégal

Ba, M.; Sall, A.; Djajhete, R.; Ba, Djibril Marie; Coumé, M.

doi:10.1016/j.npg.2023.05.005

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…The prevalence of SARS-CoV-2 infections in our sample was 2.23%. Much higher prevalences have been reported by Manirakiza and Lango Yaya during the first and second waves [19] [20].…”

Section: Discussionmentioning

confidence: 87%

Mass Screening Using Antigenic and Molecular Diagnostic Tests of COVID-19 in Bangui at the Beginning of the Second Wave in July 2021

Rafaï,

Belizaire,

Somse

et al. 2024

JTR

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Objective: COVID-19 surveillance was established as early as March 2020 in the Central African Republic (CAR), after the WHO statement relating to the identification of several cases outside China. However, given the non-performing molecular biology technical platform in many developing countries in sub-Saharan Africa, the second wave promised to be surprising and formidable. In this context, a mass survey was launched in Bangui to determine the prevalence of COVID-19. Patients and Methods: From March 18 to April 2, 2021, a mass screening campaign took place in tourist places, companies and the main hospital infrastructures. Nasopharyngeal swab samples were collected from participants with and without symptoms of Influenza-like illness (ILI) and stored in VTM tubes. The Ag (COVID-19) and RT-PCR tests were carried out in Bangui at the LNBCSP. The sequencing of RT-PCR SARS-CoV-2 positives was carried out at the INRB. Results: We included 1480 participants of whom 33 (2.23%) were SARS-COV-2 positive, of whom 24 were male and 9 female. This sex difference was statistically significant (p = 0.012) as the sex ratio M/F was 1.09. Sampling sites located in the 1st arrondissement were the most prolific (p = 0.006) and were sequenced. In addition to the analysis of the 33 samples from the predefined sites under study, 17 control sequences from the provinces generated during the same

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“…The prevalence of SARS-CoV-2 infections in our sample was 2.23%. Much higher prevalences have been reported by Manirakiza and Lango Yaya during the first and second waves [19] [20].…”

Section: Discussionmentioning

confidence: 87%

Mass Screening Using Antigenic and Molecular Diagnostic Tests of COVID-19 in Bangui at the Beginning of the Second Wave in July 2021

Rafaï,

Belizaire,

Somse

et al. 2024

JTR

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Contribution of genomic surveillance in the detection and monitoring of SARS variants- CoV-2 during the 6 pandemic waves in the Central African Republic from 2020 to 2023

RAFAÏ,

Lango-Yaya,

Belizaire

et al. 2024

Preprint

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Objective: The Covid-19 pandemic has highlighted the need to strengthen diagnosis and genomic surveillance capacities. The Central African Republic was able to manage 5 waves during health monitoring and integrated genomic surveillance as a surveillance tool in 2021. The aim of this study is to report surveillance data from the National Laboratory of Clinical Biology and Public Health and describe the landscape of circulation of SARS-CoV-2 variants. Materials and methods: This is a retrospective, descriptive observational study over a period of 3 years (ranging from April 2020 to November 2023) carried out on a population of consenting volunteers, from throughout the CAR, tested by RT -PCR on nasopharyngeal samples with sufficient information in the LNBCSP databases. Sequencing is largely carried out at the INRB in KINSHASA and from May 2023 at the LNBCSP. Results and discussion: Out of 97,864 RT-PCR tests carried out, 9,764 came back positive, which corresponds to a prevalence of 9.98%. The average age of the patients was 39.97 years ± 13.76 and the sex ratio M/F was 2.12. The positivity of RT-PCR tests was significantly associated with age (p=0.001), sex (p=0.013) and clinical manifestations. Ten variants circulated during the 5 waves recorded. The landscape of circulating variants was dominated by the Omicron (B.1.1.529), Delta (B.1.617.2) variants and especially by B.1.620 and B.640 which marked the second wave in CAR. Conclusion: This retrospective series provides key information for understanding the history of the Covid-19 pandemic in the CAR. Risk factors are identified and the variant circulation landscape described. Strengthening national genomic surveillance capacities would help the country adopt a better response against this pandemic.

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Impact of a Mass Campaign on the Evolution of the Fourth Wave of the Covid-19 Pandemic in the Central African Republic

Rafaï,

Somse,

Nambei

et al. 2024

JTR

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Objective: In the context of increasing cases despite vaccination campaigns, a survey was conducted in the Bangui population from January 17 to 26, 2022, to evaluate the strains of Severe Acute Respiratory Infection Coronavirus 2 (SARS-Cov-2) circulating in a healthy population. Materials and methods: This study was conducted by taking nasopharyngeal samples from randomly selected volunteers. Antigen detection was performed systematically, and RT-PCR was done on the positive samples. Results and discussion: We collected 2,554 samples. Thirty were found RT-PCR positive (1.2%) and sent for viral genome sequencing. Twenty-eight SARS-Cov-2 strains belonged to the Omicron type, and only 2 to the Delta type. Conclusion: Thus, infections were uncommon in the tested population, but the presence of Omicron and Delta types raises concerns that vaccination may not be effective in fighting the virus, and newly designed vaccines should be implemented to better protect the population at risk of infection and reinfection by these variants.

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Infection à Covid-19 en gériatrie au Sénégal

Cited by 4 publications

References 25 publications

Mass Screening Using Antigenic and Molecular Diagnostic Tests of COVID-19 in Bangui at the Beginning of the Second Wave in July 2021

Mass Screening Using Antigenic and Molecular Diagnostic Tests of COVID-19 in Bangui at the Beginning of the Second Wave in July 2021

Contribution of genomic surveillance in the detection and monitoring of SARS variants- CoV-2 during the 6 pandemic waves in the Central African Republic from 2020 to 2023

Impact of a Mass Campaign on the Evolution of the Fourth Wave of the Covid-19 Pandemic in the Central African Republic

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