Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review

Kivity, Shaye; Arango, Maria Teresa; Ehrenfeld, Michael; Tehori, Omer; Shoenfeld, Yehuda; Anaya, Juan Manuel; Agmon‐Levin, Nancy

doi:10.1016/j.jaut.2014.02.008

Cited by 126 publications

(82 citation statements)

References 53 publications

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“…Given the significant increase of interferon responses in SS patients, viral stimuli have been suggested as such stimuli. 3 Crossreactivity between the SSA-specific autoantibodies, which comprise a class of clinical marker for SS, and Epstein Barr Virus (EBV) EBNA-1 protein was reported, illustrating a molecular mimicry between pathogenic antigenic determinants and host self-proteins. 4 Furthermore, EBV-encoded small RNA is released by virally infected cells in complex with La/SSB protein and reinforces the connection between autoantibody generation and EBV infection.…”

Section: Introductionmentioning

confidence: 99%

TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis

Terzulli

Contreras-Ruiz

Kugadas

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

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Purpose: The potential role of commensals as triggering factors that promote inflammation in dry eye disease has not been explored. The objective of this study was to evaluate whether ocular microbiota changes with the onset of dry eye disease in thrombospondin-1-deficient (TSP-1 -/ -) mice, a strain that develops Sjögren's syndrome-like disease. Methods: Conjunctival swabs were collected from TSP-1 -/ -and C57BL/6 mice and analyzed for bacterial presence. Opsonophagocytosis of the bacterial conjunctival isolates derived from the aged TSP-1 -/ -mice by neutrophils derived from either TSP-1 -/ -or C57BL/6 bone marrow was evaluated. The bactericidal activities of TSP-1-derived peptide were examined. Results: We found that in TSP-1 -/ -mice, the conjunctival colonization with Staphylococcus aureus and coagulase negative staphylococci sp (CNS) species was significantly increased with aging and preceded that of the wild-type C57BL/6 control mice. This correlated with increased neutrophil infiltration into the conjunctiva of the TSP-1 -/ -mice, suggesting that TSP-1 plays a significant role in regulating immunity to commensals. Accordingly, the TSP-1 -/ -PMNs opsonophagocytozed the ocular commensals less efficiently than the TSP-1-sufficient neutrophils. Furthermore, a TSP-1-derived peptide, 4N1K, exhibited significant antimicrobial activity when compared to a control peptide against commensal sp. Conclusion: These studies illustrate that alterations in the commensal frequency occur in the early stages of development of Sjögren's-like pathology and suggest that interventions that limit commensal outgrowth such as the use of TSP-1-derived peptides could be used for treatment during the early stages of the disease to reduce the commensal burden and ensuing inflammation.

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Section: Introductionmentioning

confidence: 99%

TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis

Terzulli

Contreras-Ruiz

Kugadas

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

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“…While a portion of the disease can be contributed to genetic risk factors, other stimuli are hypothesized to play a role in the development of SS, such as hormone imbalance and stress. Several environmental factors are thought to be triggers for SS including Epstein-Barr virus, Hepatitis C, tuberculosis, and malaria among others [70].…”

Section: Sjogrens Syndromementioning

confidence: 99%

B cell epitope spreading: Mechanisms and contribution to autoimmune diseases

Cornaby¹,

Gibbons²,

Mayhew³

et al. 2015

Immunology Letters

155

108

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“…Some specific proteins have been suggested as a possible causal factor in the pathogenesis of multiglandular autoimmune disease [25,26]. In concurrent autoimmune thyroiditis with atrophic gastritis, antimicrosomal antibody, anti-peroxidase antibody, or antiparietal antibody have been used in an attempt to explain the relation with Concurrent autoimmune thyroiditis [11].…”

Section: Discussionmentioning

confidence: 99%

Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report

Lee¹,

Chung

Chung³

et al. 2014

Thyroid Disorders Ther

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Multiple mechanisms have been suggested for the pathogenesis of these multiglandular autoimmune diseases. One of proposed mechanisms in the multiglandular autoimmune disease is initiated by antibodies. However, the results are not definitive and remain controversial. We investigated a woman with multiple autoimmune diseases, in whose serum the mRNA of sodium iodide symporter (NIS) was found by nested reverse transcription polymerase chain reaction (RT-PCR). In this patient, multiple autoimmune diseases were initially developed as thyroiditis, followed by Sjögren syndrome, hepatitis, and finally a diagnosis of atrophic gastritis. NIS is known to be expressed on organs affected by these diseases. The mRNA of NIS was found in the serum of this patient by nested RT-PCR. The pathogenesis of multiglandular autoimmune disease is still not clear. We suggest that anti NIS antibodies can serve as a marker to monitor the pathogenesis of multiglandular autoimmune disease.

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Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review

Cited by 126 publications

References 53 publications

TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis

TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis

B cell epitope spreading: Mechanisms and contribution to autoimmune diseases

Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report

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