Infection and immune-mediated meningococcal-associated arthritis: combination features in the same patient

Arthritis secondary to invasive meningococcemia is rare and has been described as a direct result of bacteremia or as immunoallergic-type arthritis, related to the immune complex. Only a few case series have been reported.This multicenter study aimed to describe the clinical characteristics and therapeutic outcomes of arthritis secondary to meningococcal infection.We performed a 5-year retrospective study. We included all patients with inflammatory joint symptoms and proven meningococcal disease defined by the identification of Neisseria meningitidis in blood, cerebrospinal fluid, or synovial fluid. Septic arthritis was defined by the identification of N meningitidis in joint fluid. Immune-mediated arthritis was considered to be arthritis occurring after at least 1 day of invasive meningococcal disease without positive joint fluid culture.A total of 7 patients (5 males) with joint symptoms and meningococcal disease were identified. The clinical presentation was mainly oligoarticular and the knee was the most frequent joint site. Five patients had septic arthritis and 4 had immune-mediated arthritis; 2 had septic arthritis followed by immune-mediated arthritis. Immune-mediated arthritis occurred 3 to 7 days after meningococcal meningitis, and treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) led to improvement without complications.Physicians must be vigilant to the different clinical presentations in patients with arthritis associated with invasive meningococcal disease. If immune-mediated arthritis is suspected, NSAIDs are usually efficient.

show abstract

“…The combination of septic and immune-mediated meningococcal arthritis in 2 of our patients is uncommon and has rarely been reported. [6] …”

Section: Discussionmentioning

confidence: 99%

Arthritis secondary to meningococcal disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…For the first two weeks, ceftriaxone was used at a dose of 2 grams per day; then cefuroxime was used for three weeks. Also, good results are reported with the use of ciprofloxacin or penicillin [4, 5, 10]. …”

Section: Discussionmentioning

confidence: 99%

“…Other clinical presentations are meningococcemia and primary meningococcal arthritis (PMA). Meningococcemia is associated with septic arthritis in approximately 10%; on the other hand, PMA is very rare and few cases are reported in literature [4]. …”

Section: Introductionmentioning

confidence: 99%

Primary Meningococcal Type C Arthritis: A Case Report and Literature Review

Barahona

Catalán

Sato

et al. 2017

Case Reports in Orthopedics

View full text Add to dashboard Cite

Acute septic arthritis is a common clinical problem in emergency departments. Primary meningococcal arthritis (PMA) is very rare and few cases are reported in literature. D. B. M. consulted the emergency department for knee pain and fever; analysis showed that the cause was a Neisseria meningitidis type C infection. He received a treatment consisting of 2 arthroscopies and 5 weeks of antibiotics. At five weeks he returned to work and at 2 months he resumed sports (jogging and soccer) without complaints. Primary arthritis of the knee caused by Neisseria meningitidis is very rare. It has a very good response to antibiotics and arthroscopy procedure. Short-term follow-up and functional results are often good or excellent.

show abstract

“…Joint involvement is common secondary to meningitis and disseminated meningococcal disease, reaching up to 4 to 50% of subjects [ 8 , 9 ]. The primary meningococcal arthritis is a rare manifestation of the infection.…”

Section: Discussionmentioning

confidence: 99%

Primary Meningococcal Polyarthritis in an Adult Woman

Sarinho

Arcadipane

Menezes

et al. 2015

Case Reports in Medicine

View full text Add to dashboard Cite

Primary joint infection caused by the Gram-negative bacteria Neisseria meningitidis is rare. Normally, joint involvement comes secondary to meningitis or severe sepsis caused by this agent. When primary arthritis is seen, monoarthritis is the most common presentation. A meningococcal polyarthritis is described in less than 10 case reports according to current literature. This case report aims to briefly review this rare clinical event in an adult woman with no previous history of rheumatological disease. Early diagnosis of polyarthritis caused by meningococcal bacteria usually present a good prognosis when properly treated.

show abstract

Infection and immune-mediated meningococcal-associated arthritis: combination features in the same patient

Cited by 8 publications

References 9 publications

Arthritis secondary to meningococcal disease

Arthritis secondary to meningococcal disease

Primary Meningococcal Type C Arthritis: A Case Report and Literature Review

Primary Meningococcal Polyarthritis in an Adult Woman

Contact Info

Product

Resources

About