Infection and Intoxication

Abstract

Infection in human cases is often believed to be responsible for anemia. It is generally believed that lack of absorption and definite blood destruction are responsible for the anemia. Accelerated metabolism due to thyroid or dinitrophenol does not modify hemoglobin production in these standard anemic dogs. Endometritis lasting over many weeks will profoundly reduce the production of hemoglobin in the standard anemic dog. A sterile abscessalso will diminish the production of new hemoglobin in the anemic dog when liver is being fed but particularly during fasting periods when the usual abundant production of new hemoglobin is reduced to zero. Impaired absorption can be excluded as a factor of any significance in certain experiments given above. Destruction of red cells can likewise be excluded as of any significance in certain experiments given above. These experiments point to a disturbance of internal metabolism related to hemoglobin building in the body as responsible for the inhibition of hemoglobin production under these conditions. We believe this same factor is often of importance in human disease.

Bone Marrow Erythropoiesis in the Anemia of Infection, Inflammation, and Malignancy

“…This anemia is characReceived for publication 14 June 1973 and in revised form 10 December 1973. terized by: (a) decreased plasma iron and iron-binding capacity; (b) impaired release of reticuloendothelial iron into the plasma; (c) modest decrease of red cell survival; and (d) relative failure of bone marrow to increase red cell production (1)(2)(3)(4)(5)(6)(7). These clinical similarities have resulted in the classification of these anemias in a single category, the anemia of chronic disorders (ACD)1 (8).…”

Peripheral Blood and Bone Marrow in Dogs Subsequent to the Routing of Splenic Blood into the Systemic Circulation

“…1 ( fig. 1), perhaps because of the development of mange (18), experienced an unusual delay in regeneration of his erythrocyte, hemoglobin and hematocrit levels. This was accom panied by an elevation of his total white cell and neutrophile counts.…”

Blood Plasma Protein Regeneration as Influenced by Infection, Digestive Disturbances, Thyroid, and Food Proteins

“…is disturbed by the abscess intoxication slowing up plasma protein formation. In the anemic dog this last thesis has been shown to obtain for the inhibition of hemoglobin formation caused by a sterile abscess (17).…”