Infection as a complication of total knee-replacement arthroplasty. Risk factors and treatment in sixty-seven cases.

Risk of revision for infection in primary total hip and knee arthroplasty in patients with rheumatoid arthritis compared with osteoarthritis: A prospective, population‐based study on 108,786 hip and knee joint arthroplasties from the Norwegian Arthroplasty Register

“…A possible explanation might be that the vulnerable soft tissue envelope around the knee joint could make the TKR in RA patients more susceptible to infection, since the connective tissue disease RA and its potentially immunomodulating medication are risk factors for skin and soft tissue infections (29,30). Our findings of an increased risk of deep infection confirm findings in several previous reports on TKRs (5,11,15,17,18,25). For THRs, the literature is conflicting (1,14,18).…”

“…There are conflicting reports on whether this increased baseline risk of infections in RA patients might influence the risk of deep infection after primary total joint replacement surgery (1,5,(11)(12)(13)(14)(15)(16)(17)(18).…”

Prosthetic Joint Infection Risk after TKA in the Medicare Population

“…A recent study related to antibiotic-related bone cement, drawn in part from the European registry experience, noted a lack of controlled clinical trials related to the treatment of infection [14]. Despite these limitations, observational studies conducted over the past three decades suggest multiple factors may be implicated in the infection risk for patients undergoing arthroplasty, including increased operative time, longer hospital stay, obesity, simultaneous bilateral joint arthroplasty, and diagnoses of rheumatoid arthritis, myocardial infarction, and atrial fibrillation, and the lack of use of certain infection countermeasures such as antibiotic bone cement [6,14,17,18,21,23]. Thus, the current relative risk of infection in contemporary TKA as well as the relative importance of various risk factors remains under debate attributable both to the rarity of the complication, changes in the treatment and prevention of infection over time as well as the practical difficulties associated with conducting well-controlled clinical studies on this topic with long-term followup.…”

The Impact of Patellar Resurfacing in Two-Stage Revision of the Infected Total Knee Arthroplasty

“…Periprosthetic joint infection (PJI) is a devastating outcome following total knee arthroplasty (TKA), occurring in approximately 2% of cases [1,2]. Two-stage revision is currently the most reliable treatment option for an infected TKA [2].…”