Infection-Associated Clinical Outcomes in Hospitalized Medical Evacuees After Traumatic Injury: Trauma Infectious Disease Outcome Study

Tribble, David R.; Conger, Nicholas G.; Fraser, Susan; Gleeson, Todd; Wilkins, Ken; Antonille, Tanya; Weintrob, Amy; Ganesan, Anuradha; Gaskins, Lakisha J.; Ping, Li; Grandits, Greg; Landrum, Michael L.; Hospenthal, Duane R.; Millar, Eugene V.; Blackbourne, Lorne H.; Dunne, James R.; Craft, David W.; Mende, Katrin; Wortmann, Glenn; Herlihy, Rachel; McDonald, Jay R.; Murray, Clinton K.

doi:10.1097/ta.0b013e318221162e

Cited by 113 publications

(151 citation statements)

References 28 publications

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“…The Trauma Infectious Disease Outcomes Study (TIDOS) is an observational cohort study of infectious complications among military personnel injured during deployment in Iraq and Afghanistan. The full details of this project have been previously published (14). Data were collected from U.S. military personnel who sustained combat-related injuries in Afghanistan (June 2009 to August 2011), were medically evacuated to LRMC, and subsequently transferred to a military hospital in the United States: Walter Reed Army Medical Center and National Naval Medical Center (National Capital Region) and San Antonio Military Medical Center (Texas).…”

Section: Methodsmentioning

confidence: 99%

Impact of Mucorales and Other Invasive Molds on Clinical Outcomes of Polymicrobial Traumatic Wound Infections

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Impact of Mucorales and Other Invasive Molds on Clinical Outcomes of Polymicrobial Traumatic Wound Infections

et al. 2015

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“…Bacterial isolates were collected from infected patients treated at the San Antonio Military Medical Center at Fort Sam Houston, TX, following their evacuation from Afghanistan and Iraq, during a time period spanning the years 2006 to 2010. 12, 13 We characterized a total of 20 different isolates obtained either by superficial (three cases) or deep wound culture (14 cases), blood culture (two cases) or urine culture (one case), each of which belonged to one of the four most predominant species of Gram-negative bacteria leading to wound infections, ABC, P. aeruginosa and ESBL-producing K. pneumoniae and E. coli (each represented by five isolates, respectively). Pulsed field gel electrophoresis (PFGE) was used for genotypic characterization of all isolates and revealed a high degree of genotypic diversity within each of the four groups, with each of the five isolates within each group representing a distinct genotype ( Table 1).…”

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In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel

et al. 2012

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Treatment of wounded military personnel at military medical centers is often complicated by colonization and infection of wounds with pathogenic bacteria. These include nosocomially transmitted, often multidrug-resistant pathogens such as Acinetobacter baumannii-calcoaceticus complex, Pseudomonas aeruginosa and extended spectrum b-lactamaseproducing Escherichia coli and Klebsiella pneumoniae. We analyzed the efficacy of multivalent adhesion molecule (MAM) 7-based anti-adhesion treatment of host cells against aforementioned pathogens in a tissue culture infection model. Herein, we observed that a correlation between two important hallmarks of virulence, attachment and cytotoxicity, could serve as a useful predictor for the success of MAM7-based inhibition against bacterial infections. Initially, we characterized 20 patient isolates (five from each pathogen mentioned above) in terms of genotypic diversity, antimicrobial susceptibility and important hallmarks of pathogenicity (biofilm formation, attachment to and cytotoxicity toward cultured host cells). All isolates displayed a high degree of genotypic diversity, which was also reflected by large strain-to-strain variability in terms of biofilm formation, attachment and cytotoxicity within each group of pathogen. Using non-pathogenic bacteria expressing MAM7 or latex beads coated with recombinant MAM7 for anti-adhesion treatment, we showed a decrease in cytotoxicity, indicating that MAM7 has potential as a prophylactic agent to attenuate infection by multidrug-resistant bacterial pathogens.

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“…13 Participating U.S. MTFs were the National Naval Medical Center, the Walter Reed Army Medical Center, and the Brooke Army Medical Center. Demographic, trauma, and clinical inpatient data from service members with deployment-related injuries were collected through the TIDOS infectious disease module of the DoD Trauma Registry.…”

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“…Demographic, trauma, and clinical inpatient data from service members with deployment-related injuries were collected through the TIDOS infectious disease module of the DoD Trauma Registry. 13,14 Data on antimalarial prescription and duration were obtained from cohort records for patients who enrolled in TIDOS and consented to follow-up. This study was approved by the Infectious Disease Institutional Review Board of Uniformed Services University of the Health Sciences.…”

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“…15 Data on duration of antimalarial chemoprophylaxis was only captured for patients who transferred to TIDOS-participating U.S. MTFs and consented to the cohort study, and this population consists of more severely injured patients. 13 Thus, it is uncertain if these data are applicable to injured personnel at all MTFs. There also appears to be facility management differences, but we were unable to establish a cause.…”

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Compliance with Antimalarial Chemoprophylaxis Recommendations for Wounded United States Military Personnel Admitted to a Military Treatment Facility

Rini

Weintrob

Tribble

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Malaria chemoprophylaxis is used as a preventive measure in military personnel deployed to malariaendemic countries. However, limited information is available on compliance with chemoprophylaxis among trauma patients during hospitalization and after discharge. Therefore, we assessed antimalarial primary chemoprophylaxis and presumptive antirelapse therapy (primaquine) compliance among wounded United States military personnel after medical evacuation from Afghanistan (June 2009-August 2011) to Landstuhl Regional Medical Center in Landstuhl, Germany, and then to three U.S. military hospitals. Among admissions at Landstuhl Regional Medical Center, 74% of 2,540 patients were prescribed primary chemoprophylaxis and 1% were prescribed primaquine. After transfer of 1,331 patients to U.S. hospitals, 93% received primary chemoprophylaxis and 33% received primaquine. Of 751 trauma patients with available post-admission data, 42% received primary chemoprophylaxis for four weeks, 33% received primaquine for 14 days, and 17% received both. These antimalarial chemoprophylaxis prescription rates suggest that improved protocols to continue malaria chemoprophylaxis in accordance with force protection guidelines are needed.During the past decade, United States military personnel have been deployed to Afghanistan, where malaria remains a serious health threat. Approximately 77% of the Afghan population resides in areas at risk of disease transmission, which results in an estimated annual average of 77,000 cases per year.

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Infection-Associated Clinical Outcomes in Hospitalized Medical Evacuees After Traumatic Injury: Trauma Infectious Disease Outcome Study

Cited by 113 publications

References 28 publications

Impact of Mucorales and Other Invasive Molds on Clinical Outcomes of Polymicrobial Traumatic Wound Infections

Impact of Mucorales and Other Invasive Molds on Clinical Outcomes of Polymicrobial Traumatic Wound Infections

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel

Compliance with Antimalarial Chemoprophylaxis Recommendations for Wounded United States Military Personnel Admitted to a Military Treatment Facility

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