Infection by Mycobacterium chelonae at the site of administration of sarilumab for rheumatoid arthritis

Sobrín, R. Dos Santos; Gómez, Nair Pérez; Vilas, A. Souto; Suarez, M.; Pampín, Eva Pérez; López, José Ramón Antúnez; Varela, A. Mera

doi:10.1093/rheumatology/kez186

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The Role Of Mycobacterial Infections In Rheumatoid Arthri1

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2020

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“…In addition, there are reports of some other species of Mycobacterium associated with RA disease that make it difficult to treat the disease. There have been case reports of other Mycobacterium species in infections and arthritis and other parts of the body in RA patients around the world [ 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 ]. Furthermore, the risk of death in RA patients with mycobacterial infection was higher than that in patients without infection [ 13 ].…”

Section: The Role Of Mycobacterial Infections In Rheumatoid Arthrimentioning

confidence: 99%

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Jasemi

Uras

et al. 2020

Microorganisms

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Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role in determining susceptibility to RA. Among different pathogens, mycobacteria (including Mycobacterium avium subspecies paratuberculosis, MAP), and Epstein–Barr virus (EBV), have extensively been proposed to promote specific cellular and humoral response in susceptible individuals, by activating pathways linked to RA development. In this review, we discuss the available experimental and clinical evidence on the interplay between mycobacterial and EBV infections, and the development of the immune dysregulation in RA.

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Section: The Role Of Mycobacterial Infections In Rheumatoid Arthrimentioning

confidence: 99%

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Jasemi

Uras

et al. 2020

Microorganisms

View full text Add to dashboard Cite

show abstract

Infection by Mycobacterium chelonae at the site of administration of sarilumab for rheumatoid arthritis

Cited by 1 publication

References 1 publication

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

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