Infection in Renal Transplant Recipients

Fishman, Jay A.; Davis, John A.

doi:10.1016/b978-1-4160-3343-1.50033-5

Cited by 25 publications

(31 citation statements)

References 63 publications

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“…In addition, the unfavorable socioeconomic profile contributes to increase the incidence of those complications in developing countries. 1,5,7 Although the incidence of infectious episodes varies significantly in different studies, the incidence of infection is usually higher in the first months following transplantation and is directly related to the immunosuppression dose used. In the first months following renal transplantation, hospital infections predominate, mainly those located in the urinary tract and surgical wound.…”

Section: Discussionmentioning

confidence: 99%

Incidência e fatores de risco para complicações infecciosas no primeiro ano após o transplante renal

Sousa¹,

Galante²,

Barbosa

et al. 2010

J. Bras. Nefrol.

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Introduction: Infectious complications significantly increase morbidity and mortality after renal transplantation. The immunosuppression used is the main risk factor and relates directly to the incidence and severity of infectious events. Methods: This is a retrospective cohort study, which assessed the incidence of infections and their risk factors among 1,676 kidney transplant recipients during the first year of follow-up. Results: Infectious events were observed in 821 (49%) patients. The mean number of infectious episodes among patients with at least one episode was 2.3 (1 -12). The most prevalent infectious complications were as follows: urinary tract infection (31.3%); cytomegalovirus infection (12%); surgical wound infection (10.3%); herpes virus infection (9.1%); pulmonary infection (5.2%); and bloodstream infection (4.3%). Cold ischemia time and the use of deceased donor grafts were important risk factors for infectious episodes. Conclusions: Infections are highly prevalent in the first year following transplantation. The main infectious complication was urinary tract infection.

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Section: Discussionmentioning

confidence: 99%

Incidência e fatores de risco para complicações infecciosas no primeiro ano após o transplante renal

Sousa¹,

Galante²,

Barbosa

et al. 2010

J. Bras. Nefrol.

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“…Hernandez M Silva, 1,2 Maisa C S Takenaka, 1,2 Pedro M M Moraes-Vieira, 1,2,3 Sandra M Monteiro, 1,2 Maristela O Hernandez, 1,2 Wahiba Chaara, 4,5,6 Adrien Six, 4,5 Fabiana Agena, 6 Patrícia Sesterheim, 2,7 Florencia Maria Barbé-Tuana, 2,7 David Saitovitch, 2,7 Francine Lemos, 8 Jorge Kalil, 1,2 and Verônica Coelho higher expression of IGKV4-1, IGLLA and IGKV1D-13 genes (20). However, the functional implication of this B-cell gene expression signature is unclear because these genes, which code for immunoglobulin light chains, have unknown immunoregulatory functions.…”

Section: Preserving the B-cell Compartment Favors Operational Toleranmentioning

confidence: 99%

Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation

Silva

Takenaka

Moraes‐Vieira

et al. 2012

Mol Med

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Transplanted individuals in operational tolerance (OT) maintain long-term stable graft function after completely stopping immunosuppression. Understanding the mechanisms involved in OT can provide valuable information about pathways to human transplantation tolerance. Here we report that operationally tolerant individuals display quantitative and functional preservation of the B-cell compartment in renal transplantation. OT exhibited normal numbers of circulating total B cells, naive, memory and regulatory B cells (Bregs) as well as preserved B-cell receptor repertoire, similar to healthy individuals. In addition, OT also displayed conserved capacity to activate the cluster of differentiation 40 (CD40)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in Bregs, in contrast, with chronic rejection. Rather than expansion or higher activation, we show that the preservation of the B-cell compartment favors OT.

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“…1 Despite the decreasing incidence, fungal infections still affect 5% of renal transplant recipients. 2,3 Yeast infections generally occur in the first 3 months after transplantation, with a wide range in severity, from simple mucocutaneous infections to life-threatening conditions.…”

mentioning

confidence: 99%

Candida Species Contamination of Preservation Fluid—Outcome of Renal Transplantation in 6 Patients

Rodrigues

Natário

Vizinho

et al. 2013

Transplantation Proceedings

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Background. Fungal infections are a rare but important cause of morbidity and mortality in kidney transplantation. Fungal contamination of the kidney preservation fluid may, sometimes, be the cause of these infections. However, the clinical consequences of fungal contamination of this fluid are not completely understood and literature on this topic is controversial. The purpose of this study was to determine the incidence of preservation fluid contamination by fungi and its clinical consequences.

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Infection in Renal Transplant Recipients

Cited by 25 publications

References 63 publications

Incidência e fatores de risco para complicações infecciosas no primeiro ano após o transplante renal

Incidência e fatores de risco para complicações infecciosas no primeiro ano após o transplante renal

Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation

Candida Species Contamination of Preservation Fluid—Outcome of Renal Transplantation in 6 Patients

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