Infection in the intensive care unit (ICU)

Dhillon, Rishi H‐P; Clark, John L.

doi:10.1016/j.cacc.2009.01.003

Cited by 7 publications

(6 citation statements)

References 106 publications

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“…On an institutional level, screening and isolating all such infected patients with appropriate infection control practices, restricting use of broad spectrum cephalosporins across the hospital (i.e., implementing a stricter antimicrobial policy) and investigating environmental contamination are important [ 96 , 97 ].…”

Section: Infection Controlmentioning

confidence: 99%

ESBLs: A Clear and Present Danger?

Dhillon

Clark

2012

Critical Care Research and Practice

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144

141

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Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics. They are a worrying global public health issue as infections caused by such enzyme-producing organisms are associated with a higher morbidity and mortality and greater fiscal burden. Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health. This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

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Section: Infection Controlmentioning

confidence: 99%

ESBLs: A Clear and Present Danger?

Dhillon

Clark

2012

Critical Care Research and Practice

Self Cite

144

141

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Section: Infection Controlmentioning

confidence: 99%

Ventriculitis Associated with Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae after Acupuncture

Park

Ryu

2017

J Neurocrit Care

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Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics. They are a worrying global public health issue as infections caused by such enzymeproducing organisms are associated with a higher morbidity and mortality and greater fiscal burden. Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health. This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

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“…In recent years, overuse and misuse of antibiotics have led to antibiotic resistance in various countries, which is a major threat to the world (3). It is estimated that approximately 20%-50% of all antibiotics and 30% of antibiotic use in United States acute care hospitals are unnecessary or ineffective (10,11). Every year, at least 2.8 million people become infected with antibiotic-resistant infections in the United States, and more than 35 000 people die accordingly (12).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit

Marghoob

Khosravi-Khezri

2022

Avicenna J Clin Microbiol Infect

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Aim: The patients in the intensive care unit (ICU) are more susceptible to healthcare-associated infections (HAI). Higher rates of nosocomial infections in ICU patients are associated with higher morbidity, mortality, and costs. The primary outcome of our study was to investigate the relationship between antibiotic resistance and mortality in ICU patients, and the secondary outcome was to evaluate the relationship between antibiotic resistance and the length of ICU or hospital stay. Methods: A 5-year observational retrospective study was conducted on patients in the ICU of Hasheminejad Kidney Center affiliated with Iran University of Medical Sciences, Tehran, Iran from January 1, 2015, to January 1, 2020. The data related to age, gender, admission type, comorbidities, length of ICU stay, length of hospital stay, infection source, microorganism type, and resistance pattern of all isolates and outcomes were collected based on the study purpose. Results: During the 5-year study, 2899 patients were admitted to the ICU, but only 747 patients were enrolled in the study, including 426 males (57%). The median age was 65 years (19-97 years). The mean length of ICU stay was greater in culture-positive patients (8.42 vs. 3.5 days, P>0.001). Culture-positive patients had significantly higher mortality compared to culture-negative patients (63.8% vs. 36.2%, P>0.001). In our study, it was found that resistant microorganisms have increased mortality by 2.6 times in the ICU in the crude model (OR: 2.6, P>0.001). Conclusion: The findings of our study suggest that multidrug-resistant pathogens increase ICU stay and mortality.

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Infection in the intensive care unit (ICU)

Cited by 7 publications

References 106 publications

ESBLs: A Clear and Present Danger?

ESBLs: A Clear and Present Danger?

Ventriculitis Associated with Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae after Acupuncture

The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit

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