2023
DOI: 10.3390/microorganisms11041010
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Infection Induced Fetal Inflammatory Response Syndrome (FIRS): State-of- the-Art and Medico-Legal Implications—A Narrative Review

Abstract: Fetal inflammatory response syndrome (FIRS) represents the fetal inflammatory reaction to intrauterine infection or injury, potentially leading to multiorgan impairment, neonatal mortality, and morbidity. Infections induce FIRS after chorioamnionitis (CA), defined as acute maternal inflammatory response to amniotic fluid infection, acute funisitis and chorionic vasculitis. FIRS involves many molecules, i.e., cytokines and/or chemokines, able to directly or indirectly damage fetal organs. Therefore, due to FIRS… Show more

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Cited by 6 publications
(1 citation statement)
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“…Full-term newborns who develop SIRS are often those who have been exposed to risk factors such as maternal infections, prolonged rupture of membranes, or complications during delivery [16]. The presence of SIRS in this population is particularly challenging to diagnose due to the non-specific nature of its clinical presentation, which can overlap with normal neonatal physiological responses or other benign conditions [17].…”
Section: Introductionmentioning
confidence: 99%
“…Full-term newborns who develop SIRS are often those who have been exposed to risk factors such as maternal infections, prolonged rupture of membranes, or complications during delivery [16]. The presence of SIRS in this population is particularly challenging to diagnose due to the non-specific nature of its clinical presentation, which can overlap with normal neonatal physiological responses or other benign conditions [17].…”
Section: Introductionmentioning
confidence: 99%